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首页> 外文期刊>Endoscopy International Open >A prospective trial of CONfocal endomicroscopy in CYSTic lesions of the pancreas: CONCYST-01
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A prospective trial of CONfocal endomicroscopy in CYSTic lesions of the pancreas: CONCYST-01

机译：胰腺囊性病变中共聚焦内窥镜检查的前瞻性试验：CONCYST-01

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Background and study aims?Pancreatic cystic lesions (PCL) are common. While some harbor malignant potential, accurate preoperative diagnosis remains challenging. Needle-based confocal laser endomicroscopy (nCLE) via a 19G FNA needle enables real-time imaging of the cyst wall. This study evaluated the safety and utility of nCLE in patients with an indeterminate PCL undergoing EUS-FNA. Patients and methods?The CONCYST study prospectively recruited patients with indeterminate PCL attending three hepatopancreaticobiliary (HPB) referral centers in the UK, with indeterminate PCL, who required EUS-FNA between July 2014 and October 2016. Following the procedure, all patients were followed up in telephone clinic for at least 12 months. Ethical approval for the study was granted by the National Research Ethics Service (14/LO/0040). Results?Sixty-seven patient were recruited, 11 excluded and 56 included in the final analysis: 35 male, 21 female; median age 68 (range 28?–?80). Recognizable confocal images were obtained in 48 of 56 cases. Median nCLE scanning time was 5 minutes and did not exceed 10 minutes in any case. EUS-nCLE findings correlated with final diagnosis (based on imaging, cytology and multidisciplinary team review) in 43/56 (77?%) of cases, compared with 37/56 (66?%) for cytology alone (P?=?0.12). One patient experienced mild pruritus following the procedure and another developed an infected pseudocyst, which resolved with antibiotics. Conclusions?EUS-nCLE under conscious sedation in the day case setting is safe and provides additional information to standard EUS-FNA for diagnosing indeterminate PCL.
机译：背景和研究旨在？胰腺囊性病变（PCL）是常见的。虽然一些港口恶性潜力，准确的术前诊断仍然具有挑战性。通过19G FNA针的针基共聚焦激光端瘤（NCL）能够实现囊壁的实时成像。本研究评估了NCLS在患者中患者进行了不确定的PCL遭受EUS-FNA的安全性和效用。患者和方法？令人讨论的研究前瞻性地招募了在英国上去的患有3次肝癌的患者的患者，其在2014年7月至2016年7月至10月期间需要EUS-FNA。在此过程中，所有患者都进行了跟进在电话诊所至少12个月。国家研究道德服务（14 / LO / 0040）授予该研究的道德批准。结果？招募了67例患者，11名被排除在一起，56名终止分析：35名男性，21名女性;中位年龄68（范围28？ - ？80）。在56例中获得可识别的共聚焦图像。中位数扫描时间为5分钟，在任何情况下都没有超过10分钟。 eus-ncle发现与最终诊断相关（基于成像，细胞学和多学科团队评论）在43/56（77倍）的情况下，仅与单独的细胞学（p？= 0.12）相比）。一名患者经历了患者的患者，后面的程序和另一个发发了一种用抗生素解决的受感染的伪变性。结论？在日壳设置中有意识的镇静下的EUS-NCLS是安全的，并为标准EUS-FNA提供额外信息，用于诊断不确定的PCL。

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