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首页> 外文期刊>Endoscopy International Open >Endoscopic ultrasound-guided fine-needle biopsy is superior to fine-needle aspiration in assessing pancreatic neuroendocrine tumors
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Endoscopic ultrasound-guided fine-needle biopsy is superior to fine-needle aspiration in assessing pancreatic neuroendocrine tumors

机译：内窥镜超声引导的细针活检优于微针的吸入评估胰腺神经内分泌肿瘤

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Background and study aims?Pancreatic neuroendocrine tumors (PanNETs) outcomes are dependent upon grading by Ki67.?This study compared endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) to fine-needle aspiration (FNA) in assessing PanNETs. Patients and methods?All pancreatic histology for PanNET between January 2009 and June 2017 was included if EUS sampling was performed prior to surgical resection. Ki67 and grade from FNA and FNB samples was compared to surgical histology using correlation coefficient and kappa values. Subgroup analysis was performed for purely solid lesions, lesions ?2?cm and FNB needle type. Results?One hundred sixity-four patients had PanNET of which 57 underwent surgical resection. Thirty-five lesions underwent FNA and 26 FNB (4 had both) confirming PanNET. 23/ of 35 FNA samples reported Ki67/grading compared to all 26 FNB samples (P?=?0.0006). Compared to surgical histology, Ki67 on FNA correlated poorly overall (r?=?–0.08), in solid lesions (r?=?–0.102) and lesions ?2?cm (r?=?–0.149) whereas FNB correlated moderately overall (r?=?0.65), in solid lesions (r?=?0.64) and lesions ?2?cm (r?=?0.61). Tumor grade showed poor agreement (kappa) with FNA overall (0.026), in solid lesions (0.044) and lesions ?2?cm (0.00) whereas FNB showed moderate-good agreement overall (0.474), in solid lesions (0.58) and lesions ?2?cm (0.745). Fork-tip FNB needles Ki67 showed strong correlation with surgical histology (r?=?0.788) compared to reverse bevel FNB needles (r?=?0.521). Both FNB needles showed moderate agreement with tumor grade. Conclusion?FNB samples were significantly more likely than FNA to provide adequate material for Ki67/grading and showed a closer match to surgical histology. FNB needle types require prospective investigation.
机译：背景和研究目标？胰腺神经内分泌肿瘤（Pannets）结果依赖于Ki67的级别。？该研究在评估Pannets中将内窥镜超声引导的细针活检（EUS-FNB）与微针吸入（FNA）进行比较。患者和方法？如果在手术切除之前进行EUS取样，则包括2009年1月至2017年6月至2017年6月间Pannet的胰腺组织学。使用相关系数和κ值与外科组织学相比，与kappa值进行比较Ki67和Fnb样品。对纯固体病变进行亚组分析，病变<2℃和FNB针型。结果？一百六十四名患者的培养件，其中57篇手术切除。三十五个病变接受了FNA和26fnb（4次）确认培养。与所有26个FNB样品相比，23 / of 35个FNA样品报告KI67 /级（P？= 0.0006）。与手术组织学相比，在固体病变中总体（r？=Δ-0.08）ki67与固体病变（r？=Δ-0.02）和病变<2≤cm（r？= -0.149），而Fnb适度相关总体（r？= 0.65），固体病变（r？= 0.64）和病变<α2≤cm（r？= 0.61）。肿瘤级显示出差的协议（Kappa）整体（0.026），固体病变（0.044）和病变<2？cm（0.00），而Fnb在固体病变中显示出中等良好的协议（0.474），并且在固体病变（0.58）和病变<？2？cm（0.745）。与反向斜面FNB针相比，Fork-tip FNB针KI67显示出与外科组织学（R？= 0.788）相关的强烈相关性（R？= 0.521）。 FNB针均显示与肿瘤等级中等协议。结论？FNB样品比FNA显着更可能为Ki67 /级的足够材料提供，并且与手术组织学相提并论。 FNB针类型需要预期调查。

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