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首页> 外文期刊>Endoscopy International Open >Multiple stents are not superior to single stent insertion for pain relief in patients with chronic pancreatitis: a retrospective comparative study
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Multiple stents are not superior to single stent insertion for pain relief in patients with chronic pancreatitis: a retrospective comparative study

机译：多个支架不优于单支架插入慢性胰腺炎患者的疼痛缓解：回顾性比较研究

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Background and study aims?Patients with painful chronic pancreatitis (CP) and distal main pancreatic duct (MPD) stricture are considered candidates for treatment using a single plastic stent insertion. Multiple side-by-side stents have been proposed as an alternative treatment but comparative studies are lacking. The aim of this retrospective study is to assess differences in characteristics and treatment outcomes in patients with CP and MPD strictures treated with a different number of stents during the stenting period. Patients and methods?Patients with painful CP and distal MPD obstruction requiring endoscopic treatment (01.2004?–?12.2012) were considered. The study population was divided in three groups: Patients treated with (A) exclusively one stent; (B) one or two stents; and (C) exclusively two stents during the stenting period. Patient characteristics and treatment outcomes were retrospectively assessed. Results?Among 284 patients, 85 were selected according to inclusion criteria (Group A: 18, Group B: 35, Group C: 32). Median follow-up duration was 84 months. The median number of endoscopic procedures needed was higher for group B [3 (A) vs. 3 (C) vs. 4 (B), P?=?0.001]. Regarding outcome, successful endoscopic treatment was lower in Group C (50?% vs. 88.2?% and 74.2?% for groups A and B, respectively; P?=?0.02). This difference was attributed to better clinical outcome in Group A compared to Group C patients [OR(95%CI): 7.50 (1.46?–?38.70); P?=?0.04]. Moreover, group C patients experienced higher levels of pain at the end of follow-up period [median Izbicki Score 0 (group A) vs. 0 (group B) vs. 6 (group C), P?=?0.03]. Conclusions?In patients with painful CP and distal MPD obstruction, treatment with a single stent is associated with better clinical outcome compared to treatment with exclusively two stents during the stenting period.
机译：背景和研究旨在患有慢性胰腺炎（CP）和远端主要胰管（MPD）狭窄的患者被认为是使用单个塑料支架插入治疗的候选者。已经提出了多个并排支架作为替代处理，但缺乏比较研究。该回顾性研究的目的是评估在支架期间用不同数量的支架治疗CP和MPD狭窄的特征和治疗结果的差异。患者和方法？考虑了患有疼痛的CP和远端MPD梗阻的患者，需要内窥镜治疗（01.2004？ - ？ - ？12.2012）。该研究人群分为三组：（a）的患者专用于一支支架; （b）一两支支架; （c）在支架期间仅仅是两个支架。回顾性评估患者特征和治疗结果。结果？在284例患者中，根据含有标准选择85名（A组：18，B组：35组，C组：32）。中位后续时间为84个月。 B组所需的内窥镜程序数量较高[3（a）对3（c）vs.4（b），p？= 0.001]。关于结果，分别在C组（分别为A和B组50μmvs.88.2μm和74.2μm，50μl％的50〜88.2〜50〜74.2μl％的成功内窥镜处理; p？= 0.02）。与C组患者[或（95％CI）：7.50（1.46？ - 38.70）相比，这种差异归因于组A组中的临床结果; p？= 0.04]。此外，C组患者在随访期结束时经历了更高水平的疼痛[中位Izbicki评分0（A组）与0（B组）与6（C组），P？= 0.03]。结论？在患有疼痛的CP和远端MPD梗阻的患者中，与单个支架的治疗有关，与在支架期间的两个支架中的两个支架进行治疗相比，具有更好的临床结果。

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