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首页> 外文期刊>Endoscopy International Open >Gastric mucosal devitalization improves blood pressure, renin and cardiovascular lipid deposition in a rat model of obesity
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Gastric mucosal devitalization improves blood pressure, renin and cardiovascular lipid deposition in a rat model of obesity

机译：胃粘膜缺陷改善肥胖大鼠模型中的血压，肾素和心血管脂质沉积

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Background and study aims?In lieu of the drawbacks of metabolic surgery, a method of mimicking resection of the gastric mucosa could be of value to those with obesity-related cardiovascular disease (CVD). Our study aims to investigate the effect of gastric mucosal devitalization (GMD) on blood pressure (BP) and cardiovascular lipid deposition in a rat model of obesity. Methods?GMD of 70?% of the stomach was achieved by argon plasma coagulation. GMD was compared to sleeve gastrectomy (SG) and sham (SH) in a high-fat-diet-induced rat model of obesity (48 rats). At 8 weeks, we measured noninvasive BP, renin, vessel relaxation and ghrelin receptor regulation in the aorta. In addition, we quantified cardiac lipid deposition and lipid droplet deposition in cardiac muscle and aorta. Results?GMD and SG were observed to have similar reductions in body weight, visceral adiposity, and serum lipid profile compared to SH rats. GMD resulted in a significant reduction in arterial BP compared to SH. Furthermore, there were significant reductions in plasma renin activity and percentage of phenylnephrine constriction to acetylcholine at the aortic ring in GMD rats compared to SH, providing insights into the mechanisms behind the reduced BP. Interestingly, the reduced BP occurred despite a reduction in endothelial ghrelin recteptor activation. Cardiac lipid content was significantly reduced in GMD rats. Lipid deposition, as illustrated by Nile Red stain, was reduced in cardiac muscle and the aorta. Conclusion?GMD resulted in a significant improvement in BP, renin and cardiovascular lipid deposition. GMD deserves further attention as a method of treating obesity-related CVD. sup*/sup These authors contributed equally.
机译：背景和研究旨在？代替代谢手术的缺点，模仿胃粘膜切除切除的方法可能对具有肥胖相关的心血管疾病（CVD）的价值。我们的研究旨在探讨胃黏膜挥发性化（GMD）对肥胖大鼠血压（BP）和心血管脂质沉积的影响。方法是通过氩血浆凝固实现70粒胃的GMD。将GMD与袖子胃切除术（SG）和Sham（Sh）进行比较，高脂肪饮食诱导的肥胖大鼠模型（48只大鼠）。在8周，我们在主动脉中测量了非侵入性BP，肾素，血管松弛和Ghrelin受体调节。此外，我们在心肌和主动脉中量化心脏脂质沉积和脂液滴沉积。结果？与SH大鼠相比，观察到GMD和SG的体重，内脏脂肪性和血清脂质分布类似。与SH相比，GMD导致动脉BP的显着降低。此外，与SH相比，GMD大鼠主动脉环上的乙酰胆碱对乙酰胆碱的血浆肾小球素百分比对乙酰胆碱的百分比进行了显着降低，提供了进入降低BP后面的机制的见解。有趣的是，尽管内皮疟原虫直肠活化剂的激活减少，但仍发生降低的BP。 GMD大鼠的心脏脂质含量显着降低。如尼罗红染色所示，脂质沉积在心肌和主动脉中减少。结论？GMD导致BP，肾素和心血管脂质沉积的显着改善。 GMD应该得到进一步关注，作为治疗肥胖相关的CVD的方法。 * 这些作者平均贡献。

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