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首页> 外文期刊>Endoscopy International Open >Feasibility and safety study of 22-gauge endoscopic ultrasound (EUS) needles for portal vein sampling in a swine model
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Feasibility and safety study of 22-gauge endoscopic ultrasound (EUS) needles for portal vein sampling in a swine model

机译：22型尺度内窥镜超声（EUS）针的可行性和安全性研究在猪模型中的门静脉抽样

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Background and study aims?Endoscopic ultrasound (EUS) has been used for portal vein sampling in patients with pancreaticobiliary cancers for enumerating circulating tumor cells but is not yet a standard procedure. Further evaluation is needed to refine the methodology. Therefore, we evaluated the feasibility and safety of 19-gauge (19G) versus a 22-gauge (22?G) EUS fine-needle aspiration needles for portal vein sampling in a swine model. Methods?Celiotomy was performed on two farm pigs. Portal vein sampling occurred transhepatically. We compared 19?G and 22?G needles coated interiorly with saline, heparin or ethylenediaminetetraacetic acid (EDTA). Small- (10?mL) and large- (25?mL) volume blood collections were evaluated. Two different collection methods were tested: direct-to-vial and suction syringe. A bleeding risk trial for saline-coated 19?G and 22?G needles was performed by puncturing the portal vein 20 times. Persistent bleeding after 3 minutes was considered significant. Results?All small-volume collection trials were successful except for 22?G saline-coated needles with direct-to-vial method. All large-volume collection trials were successful when using suction syringe; direct-to-vial method for both 19?G and 22?G needles were unsuccessful. Collection times were shorter for 19?G vs. 22?G needles for both small and large-volume collections (P??0.05). Collection times for saline-coated 22?G needles were longer compared to heparin/EDTA-coated (P??0.05). Bleeding occurred in 10?% punctures with 19?G needles compared to 0?% with 22?G needles. Conclusion?The results of this animal study demonstrate the feasibility and the safety of using 22?G needles for portal vein sampling and can form the basis for a pilot study in patients.
机译：背景和研究旨在？内窥镜超声（EUS）已被用于胰岛癌患者的门静脉抽样，用于枚举循环肿瘤细胞但尚未进行标准程序。需要进一步评估来细化方法。因此，我们评估了19-Cauge（19G）的可行性和安全性，而在猪模型中的门静脉采样的22·仪表（22μg）EUS细针吸入针。方法？芹菜术在两只农场猪进行。门静脉抽样经常发生。我们将19〜g和22？g的针对与盐水，肝素或乙二胺四乙酸（EDTA）进行室内涂覆。评估小 - （10？mL）和大（25μl）体积血液收集。测试了两种不同的收集方法：直瓶和吸入注射器。通过将门静脉脉冲20次来进行盐水涂覆19μg和22μg针的出血风险试验。 3分钟后持续出血被认为是显着的。结果？除了22〜G盐水涂层针，外针涂有直瓶种的针头，所有小批量收集试验都是成功的。使用吸入注射器时，所有大容量的收集试验都是成功的;用于19？G和22？G针的直瓶方法是不成功的。对于小型和大容量收集，收集时间为19？G与22？G针刺较短（P？<？0.05）。与肝素/ EDTA涂层相比，盐水涂层22μm2的收集时间（P？<β05）。出血发生在10？％穿孔中，19？G针相比，22？G针相比。结论？这种动物研究的结果证明了用于门静脉抽样的22？G针的可行性和安全性，可以为患者的试验研究形成基础。

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