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首页> 外文期刊>Endocrine journal >Highly Increased Insulin Secretion in a Patient with Postprandial Hypoglycemia
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Highly Increased Insulin Secretion in a Patient with Postprandial Hypoglycemia

机译：高度增加的患者在患有餐后低血基血症的患者中分泌

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References(19) Cited-By(3) The mechanism(s) of an inappropriate secretion of insulin is poorly understood. We report a case of reactive hypoglycemia associated with an unusually exaggerated insulin secretion. The patient, a 32-year-old man, developed frequent episodes of postprandial hypoglycemia after interferon treatment was begun for chronic type C hepatitis. Oral glucose challenge test confirmed the patient's extremely high plasma IRI response, i.e., more than 1000μU/ml, and that of plasma C-peptide 56.9ng/ml at 90 min, followed by symptomatic hypoglycemia (plasma glucose 34mg/dl) at 240min. The plasma proinsulin level also was high, but the molar ratio of immuno reactive insulin (IRI)/plasma C-peptide and IRI/proinsulin was within the normal range. Antibodies to insulin or insulin-receptor were negative. Plasma IRI response was apparently greater when the glucose was given orally than when given intravenously. The response of plasma glucagon-like-peptide (GLP)-1 to oral glucose was quite high (from baseline of 45.5 to 303.2pmol/L) and showed a close parallel with the change in the plasma IRI concentration. The greatly enhanced insulin secretion leading to reactive hypoglycemia in this patient may therefor be attributed to the increased secretion of GLP-1.
机译：参考文献（19）被引用（3）胰岛素的不恰当分泌的机制很差。我们报告了与异常夸张的胰岛素分泌相关的反应性低血糖的情况。患者，一名32岁的人，在干扰素治疗后，慢性急性肝炎开始后发育频繁的黄疸低血基血症。口服葡萄糖攻击试验证实患者的极高血浆IRI反应，即超过1000μU/ ml，血浆C-肽56.9ng / ml在90分钟，然后在240分钟的症状低血糖（血浆葡萄糖34mg / d1）。等离子体胰蛋白酶水平也很高，但免疫反应性胰岛素（IRI）/血浆C-肽和IRI / PIRINNULIN的摩尔比在正常范围内。对胰岛素或胰岛素受体的抗体是阴性的。当葡萄糖口服时，血浆IRI响应显然更大，而不是静脉内给出时。血浆胰高血糖素样肽（GLP）-1对口腔葡萄糖的响应非常高（从45.5至303.2pmol / L的基线），并且随着血浆IRI浓度的变化而显示平行。在该患者中，导致具有活性低血糖症的大大增强的胰岛素分泌可能归因于GLP-1的分泌增加。

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