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首页> 外文期刊>Endocrine journal >Evaluation of the relationship between glycated hemoglobin A1c and mean glucose levels derived from the professional continuous flash glucose monitoring system
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Evaluation of the relationship between glycated hemoglobin A1c and mean glucose levels derived from the professional continuous flash glucose monitoring system

机译：糖化血红蛋白A1C与源于专业闪光葡萄糖监测系统的平均血糖水平的关系评价

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Previously, we reported that short-term continuous glucose monitoring (CGM) with the professional iPro2? CGM device is a good clinical indicator of glycated hemoglobin (HbA1c) levels. However, there was no significant correlation between CGM and HbA1c levels when HbA1c levels were 8.0%. To further investigate this issue, we performed a similar study using the FreeStyle Libre Pro?, a newer device that does not require glucose calibration and allows patients to be examined for up to 14 days. Fifty-nine patients (68% women, 32% men) were examined. Twenty-eight and 31 patients presented with type 1 and type 2 diabetes, respectively. Clinically assessed HbA1c levels were compared to blood glucose levels determined by the FreeStyle Libre Pro? for up to 14 days (10.7 ± 3.7 days). We found a significant correlation between HbA1c and CGM levels even when HbA1c levels were 8.0%. Additionally, the correlation between HbA1c and average glucose was identified with the modern CGM and was found to deviate substantially from the new suggested formula. More importantly, we found a more robust correlation between HbA1c and CGM levels in patients with type 2 diabetes. Overestimation or underestimation of blood glucose levels through CGM might increase the risks of inappropriate clinical treatment of diabetes patients. Our results indicate the need for proper CGM data interpretation individualized for each patient to better assist the determination of customized treatments for patients.
机译：以前，我们报告说短期连续葡萄糖监测（CGM）与专业的IPRO2？ CGM装置是糖化血红蛋白（HBA1C）水平的良好临床指标。然而，当HBA1C水平> 8.0％时，CGM和HBA1C水平之间没有显着相关性。为了进一步调查此问题，我们使用自由式Libre Pro的类似研究进行了类似的研究，该较新的设备不需要葡萄糖校准，并允许患者在最多14天内进行检查。检查了五十九名患者（68％女性，32％的男性）。 28和31名患者分别呈现1型和2型糖尿病。将临床评估的HBA1C水平与由自由式Libre Pro确定的血糖水平进行比较？最多14天（10.7±3.7天）。我们发现HBA1C和CGM水平之间的显着相关性，即使HBA1C水平> 8.0％。另外，HBA1C与平均葡萄糖之间的相关性与现代CGM鉴定，发现基本上偏离了新的建议公式。更重要的是，我们发现2型糖尿病患者的HBA1C和CGM水平之间的更强相关性。通过CGM的高估或低估血糖水平可能会增加糖尿病患者的不适当临床治疗的风险。我们的结果表明，需要适当的CGM数据解释，每个患者的个性化，以更好地协助确定患者的定制治疗方法。

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