The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs

Martha L. Slattery; Lila E. Mullany; Roger K. Wolff; Lori C. Sakoda; Wade S. Samowitz; Jennifer S. Herrick

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The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs

机译：P53信号通路和结直肠癌：下游P53靶基因与miRNA之间的相互作用

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IntroductionWe examined expression of genes in the p53-signaling pathway. We determine if genes that have significantly different expression in carcinoma tissue compared to normal mucosa also have significantly differentially expressed miRNAs. We utilize a sample of 217 CRC cases.

机译：介绍我们在P53信号通路中检查了基因的表达。我们确定与正常粘膜相比癌组织中具有显着不同表达的基因也具有显着差异表达的miRNA。我们利用217个CRC病例的样本。

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《Genomics》 |2019年第4期|共10页
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Martha L. Slattery; Lila E. Mullany; Roger K. Wolff; Lori C. Sakoda; Wade S. Samowitz; Jennifer S. Herrick;
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Colorectal CancerTP53miRNAmRNACRCcolorectal cancerFDRfalse discovery rateFCfold changeKPNCKaiser Permanente of Northern CaliforniaKEGGKyoto Encyclopedia of Genes and GenomicsHRHazard RatiomiRNAmicroRNAMSImicrosatellite instabilityMSSmicrosatellite stableQCquality controlSEERSurveillance Epidemiology and End ResultsTGtarget geneTFtranscription factorUTRuntranslated region;

机译：结肠直肠癌53mirnamrnacrcrcolorectal cancerfrfalse发现率FFCold Changekpnckaiser Eventeree of Californiakgkgkyoto基因百科全书和基因组学症状RatiomirnamicrornamsimiCrosatellite不含不稳定性的稳定性QuqualityContrysurveillance流行病学和最终结果术术反对派;

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1. The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs [J] . Slattery Martha L., Mullany Lila E., Wolff Roger K., Genomics . 2019,第4期

机译：P53信号通路和结直肠癌：下游P53靶基因与miRNA之间的相互作用
2. Anomalous altered expressions of downstream gene-targets in TP53-miRNA pathways in head and neck cancer [J] . Sanga Mitra, Nupur Mukherjee, Smarajit Das, Scientific reports. . 2014,第1期

机译：头颈癌TP53-miRNA通路中下游基因靶标的异常改变
3. Analysis of the expression of miRNAs and downstream target genes in gastric cancer tissue and exploration of its relationship with clinicopathologic stage [J] . Zhen Xiong 海南医科大学学报（英文版） . 2016,第008期

机译：胃癌组织中miRNA和下游靶基因的表达分析及其与临床病理分期的关系
4. The inference of gene co-expression networks of breast and colon cancer using miRNA-target gene interactions data [C] . Mustafa Özgür Cingiz, Banu Diri Signal Processing and Communications Applications Conference . 2017

机译：利用miRNA-靶标基因相互作用数据推断乳腺癌和结肠癌的基因共表达网络
5. p53 acetylation and downstream target gene activation in LNCaP prostate cancer cells [D] . Roy, Somdutta. 2006

机译：LNCaP前列腺癌细胞中的p53乙酰化和下游靶基因激活
6. The p53-signaling pathway and colorectal cancer: interactions between downstream p53 target genes and miRNAs [O] . Martha L. Slattery, Lila E. Mullany, Roger K. Wolff, -1

机译：p53信号通路与大肠癌：下游p53靶基因与miRNA之间的相互作用
7. Anomalous altered expressions of downstream gene-targets in\ud TP53-miRNA pathways in head and neck cancer [O] . Mitra, Sanga, Mukherjee, Nupur, Das, Smarajit, 2014

机译：下游基因靶标的异常表达改变 Tp53-miRNa在头颈癌中的途径

The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs

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