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首页> 外文期刊>Genomics >Peripheral rods: a specialized developmental cell type in Myxococcus xanthus
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Peripheral rods: a specialized developmental cell type in Myxococcus xanthus

机译：外围棒：丘神肌中的专业发育细胞类型

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In response to nutrient deprivation, the ubiquitous Gram-negative soil bacterium Myxococcus xanthus undergoes a well-characterized developmental response, resulting in the formation of a multicellular fruiting body. The center of the fruiting body consists of myxospores; surrounding this structure are rod-shaped peripheral cells. Unlike spores, the peripheral rods are a metabolically active cell type that inhabits nutrient-deprived environments. The survival characteristics exhibited by peripheral rods, protection from oxidative stress and heat shock, are common survival characteristics exhibited by cells in stationary phase including modifications to morphology and metabolism. Vegetative M. xanthus cells undergo a number of physiological changes during the transition into stationary phase similar to other proteobacteria. In M. xanthus, stationary-phase cells are not considered a component of the developmental response and occur when cells are grown on nutrient-rich plates or in dispersed aqueous media. However, this cell type is not routinely studied and little of its physiology is known. Similarities between these two stress-induced cell types led to the question of whether peripheral rods are actually a distinct developmental cell type or simply cells in stationary phase. In this study, we examine the transcriptome of peripheral rods and its relationship to development. This work demonstrates that peripheral rods are in fact a distinct developmentally differentiated cell type. Although peripheral rods and stationary phase cells display similar characteristics, each transcriptomic pattern is unique and quite different from that of any other M. xanthus cell type.
机译：响应营养剥夺，普遍存在的革兰氏阴性土壤细菌菌丝菌丘疹Xanthus经历了一种良好的发育反应，导致形成多细胞果实体。果实的中心由肌孢子组成;围绕这种结构是棒状周边电池。与孢子不同，外周棒是一种代谢活性的细胞类型，其栖息地剥夺了环境。外围杆，保护氧化应激和热休克的存活特性是静止阶段中细胞表现出的常见存活特性，包括对形态和代谢的修饰。在过渡到类似于其他植物的固定相，Xanthus细胞Xanthus细胞经历了许多生理变化。在M. Xanthus，固定相细胞不被认为是发育反应的组分，并且当细胞在富含营养素的平板或分散的水性介质中生长细胞时发生。然而，这种细胞类型不常规研究，并且他的生理学很少是已知的。这两个应激诱导的细胞类型之间的相似性导致外围杆是否实际上是一种不同的发育细胞类型或简单的静止相中细胞的问题。在这项研究中，我们检查外围杆的转录组及其与发育的关系。这项工作表明，外周棒实际上是一种不同的显影分化细胞类型。虽然外周杆和固定相电池显示相似的特征，但每个转录组图案是独特的，与任何其他M. Xanthus细胞类型的不同。

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