• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genomics >Differential gene expression of Plasmodium homocircumflexum (lineage pCOLL4) across two experimentally infected passerine bird species
【24h】

Differential gene expression of Plasmodium homocircumflexum (lineage pCOLL4) across two experimentally infected passerine bird species

机译：两种实验感染偏航鸟类（谱系PCOLL4）疟原虫同源疟原虫（谱系PCOLL4）的差异基因表达

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Plasmodium parasites are present in a wide range of host species, some of which tend to be more susceptible than others, potentially as an outcome of evolved tolerance or resistance. Common starlings seem to cope with malaria infection while common crossbills are more susceptible to the same infections. That raises the question if the parasites rely on the same molecular mechanisms regardless of host species or do Plasmodium parasites change gene-expressions in accordance to the environment different hosts might provide? We used RNA-sequencing from starlings and crossbills, experimentally infected with Plasmodium homocircumflexum (lineage pCOLL4). The assembled transcriptome contained a total of 26,733 contigs. Parasite expression patterns differed between bird species. Parasites had higher expression of cell-invasion genes when infecting crossbills compared to starlings whereas in starlings genes related to apoptosis or/and oxidative stress showed higher expression levels. This article reveals how a Plasmodium parasite might adjust its expression and gene function depending on the host species infected.
机译：疟原虫寄生虫在各种宿主物种中存在，其中一些往往比其他宿主物种更容易受到更容易受到影响，可能是耐受性或抗性的结果。常见的椋鸟似乎应对疟疾感染，而常见的十字架更容易受到同样感染的影响。如果寄生虫依赖于相同的分子机制，无论宿主物种如何或饲料寄生虫，根据环境不同的宿主可能提供不同的宿主，那么我们使用RNA测序从椋鸟和十字架上进行测序，实验地感染了疟原虫同性律（谱系PCOLL4）。组装的转录组总共含有26,733个葡萄片。寄生虫表达模式不同于鸟类。当与饥饿相比，寄生虫在感染横谱时具有更高的细胞侵入基因表达，而在与凋亡或/和氧化应激相关的辛酸基因中显示出更高的表达水平。本文揭示了疟原虫寄生虫如何根据感染的宿主物种调节其表达和基因功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号