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首页> 外文期刊>Genomics >Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage
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Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage

机译：全血液中血液的圆形RNA表达改变，具有静脉内的白质损伤

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Circular RNAs (circRNAs) are evolutionarily conserved and tissue-specific types of non-coding RNA and can serve as potential diagnostic biomarkers for disease. However, the clinical significance and levels of expression of circRNAs for whole blood samples of prematurely born infants afflicted by diseases such as periventricular white matter damage (PWMD) are largely unknown. Therefore, we sought to identify measures of expression of circRNAs in whole blood samples obtained from prematurely born infants afflicted by PWMD and comparatively in samples from prematurely born infants without PWMD. We found the expression levels of circRNAs which from premature with PWMD has changed. Further analysis suggests that these circRNAs have important roles in PWMD. This study can improve the understanding for the potential of the circRNAs to serve as biomarkers in PWMD. Moreover, these circRNAs may provide evidence for improving diagnosis and treatment for infants afflicted by PWMD, and merits continued research.
机译：圆形RNA（CircRNA）是进化的保守和组织特异性类型的非编码RNA，并且可以作为疾病的潜在诊断生物标志物。然而，患有疾病（PWMD）患病的过早出生婴儿的整体血液样本的临床意义和表达水平在很大程度上。因此，我们试图识别从PWMD过早出生婴儿获得的全血样品中CircRNA表达的措施，并且在没有PWMD的过早出生婴儿的样品中相互作用。我们发现来自PWMD的早产的Circrnas的表达水平已发生变化。进一步的分析表明，这些Circrnas在PWMD中具有重要作用。本研究可以改善对Circrnas潜力作为PWMD中的生物标志物的潜力的理解。此外，这些Circrnas可以提供改善PWMD患病的诊断和治疗的证据，并优雅持续研究。

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