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首页> 外文期刊>Frontiers in Microbiology >Cesarean or Vaginal Birth Does Not Impact the Longitudinal Development of the Gut Microbiome in a Cohort of Exclusively Preterm Infants
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Cesarean or Vaginal Birth Does Not Impact the Longitudinal Development of the Gut Microbiome in a Cohort of Exclusively Preterm Infants

机译：剖宫产或阴道出生不会影响肠道微生物组的纵向发育在完全早产儿的队列中

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The short and long-term impact of birth mode on the developing gut microbiome in neonates has potential implications for the health of infants. In term infants, the microbiome immediately following birth across multiple body sites corresponds to birth mode, with increased Bacteroides in vaginally delivered infants. We aimed to determine the impact of birth mode of the preterm gut microbiome over the first 100 days of life and following neonatal intensive care unit (NICU) discharge. In total, 867 stool samples from 46 preterm infants (21 cesarean and 25 vaginal), median gestational age 27 weeks, were sequenced (V4 region 16S rRNA gene, Illumina MiSeq). Of these, 776 samples passed quality filtering and were included in the analysis. The overall longitudinal alpha-diversity and within infant beta-diversity was comparable between cesarean and vaginally delivered infants. Vaginally delivered infants kept significantly more OTUs from 2 months of life and following NICU discharge, but OTUs lost, gained, and regained were not different based on birth mode. Furthermore, the temporal progression of dominant genera was comparable between birth modes and no significant difference was found for any genera following adjustment for covariates. Lastly, preterm gut community types (PGCTs) showed some moderate differences in very early life, but progressed toward a comparable pattern by week 5. No PGCT was significantly associated with cesarean or vaginal birth. Unlike term infants, birth mode was not significantly associated with changes in microbial diversity, composition, specific taxa, or overall microbial development in preterm infants. This may result from the dominating effects of NICU exposures including the universal use of antibiotics immediately following birth and/or the lack of Bacteroides colonizing preterm infants.
机译：诞生模式对新生儿的肠道微生物组的短期和长期影响对婴儿的健康有潜在的影响。在术语婴儿中，在多个身体部位出生后的微生物组对应于出生模式，具有较大的婴儿菌株增加。我们的目标是在生命的前100天和新生儿重症监护室（NICU）排放后，确定早产肠道微生物组的出生模式的影响。总共867个早产儿（21个剖宫产和25例阴道），27周的中位孕龄（21个剖宫产和25个阴道），被测序（V4区16S rRNA基因，Illumina miseq）。其中，776个样品通过质量过滤，并包括在分析中。整体纵向α-多样性和婴儿β多样性在剖腹产和阴道递送的婴儿之间是可比的。阴道递送的婴儿从生命的2个月和Nicu放电后保持更多的Otus，但oTus丢失，获得，并根据出生模式没有不同。此外，占主导地段的时间进展在出生模式之间具有可比性，并且在调整协变量后任何一般都没有发现显着差异。最后，早产肠道群落类型（PGCTS）在非常初期的寿命中显示出一些中等的差异，但在第5周之前朝着相当的模式进行了比较。没有PGCT与剖宫产或阴道出生有显着相关。与术语婴儿不同，出生模式与早产儿的微生物多样性，组成，特异性分类群或整体微生物发育的变化没有显着相关。这可能是由尼古尔暴露的主导作用导致包括普遍使用抗生素的普遍用途和/或缺乏菌株殖民定植早产儿。

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