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首页> 外文期刊>Frontiers in Cell and Developmental Biology >Repositioning Lidocaine as an Anticancer Drug: The Role Beyond Anesthesia
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Repositioning Lidocaine as an Anticancer Drug: The Role Beyond Anesthesia

机译：将利多卡因重新定位为抗癌药物：超越麻醉的角色

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While cancer treatment has improved dramatically, it has also encountered many critical challenges, such as diseases recurrence, metastasis and drug resistance, making new drugs of novel mechanisms the urgent clinical need. The term drug repositioning, also known as old drugs for new uses, has emerged as one practical strategy to develop new anticancer drugs. Anesthetics have been widely used in surgical procedures to reduce the excruciating pain. Lidocaine, one of the most used local anesthetics in clinical settings, has been found to show multi-activities, including its potential in cancer treatment. Growing evidence shows that lidocaine may not only work as a chemosensitizer that sensitizes other conventional chemotherapeutics to certain resistant cancer cells, but also could suppress cancer cells growth by single use at different doses or concentrations. Lidocaine could suppress cancer cell growth in vitro and in vivo via multiple mechanisms, such as regulating epigenetic changes, promoting pro-apoptosis pathways, as well as regulating ABC transporters, metastasis and angiogenesis, etc., providing valuable information for its further application in cancer treatment and for new drug discovery. In addition, lidocaine is now under clinical trials to treat certain types of cancer. In the current review, we summarize the research and analyze the underlying mechanisms, and address key issues in this area.
机译：虽然癌症治疗急剧提高，但它也遇到了许多关键挑战，例如疾病复发，转移和耐药性，使新的新型机制迫切需要临床需求。术语重新定位，也称为新用途的旧药物，已成为开发新的抗癌药物的一种实际策略。麻醉剂已被广泛应用于手术程序，以减少令人讨厌的疼痛。 Lidocaine是临床环境中最常用的局部麻醉剂之一，已被发现显示多项活动，包括其癌症治疗的潜力。日益增长的证据表明，利多卡因不仅可以作为化学敏化剂，可以使其他常规化学治疗剂敏感到某些抗性癌细胞，还可以通过单一用剂量或浓度来抑制癌细胞生长。 Lidocaine可以通过多种机制抑制体外和体内癌细胞生长，例如调节表观遗传变化，促进促凋亡途径，以及调节ABC转运液，转移和血管生成等，为其在癌症中的进一步应用提供有价值的信息治疗和新药发现。此外，利多卡因现在正在临床试验中治疗某些类型的癌症。在目前的审查中，我们总结了研究和分析潜在机制，并解决了该领域的关键问题。

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