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首页> 外文期刊>Frontiers in Neurology >Identifying Morphological Patterns of Hippocampal Atrophy in Patients With Mesial Temporal Lobe Epilepsy and Alzheimer Disease
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Identifying Morphological Patterns of Hippocampal Atrophy in Patients With Mesial Temporal Lobe Epilepsy and Alzheimer Disease

机译：鉴定患有患者颞叶癫痫和阿尔茨米默病患者的海马萎缩形态学模式

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Purpose: Mesial temporal lobe epilepsy (MTLE) and Alzheimer's disease (AD) are two distinct neurological disorders associated with hippocampal atrophy. Our goal is to analyze the morphologic patterns of hippocampal atrophy to better understand the underlying pathological and clinical characteristics of the two conditions. Methods: Twenty-five patients with AD and 20 healthy controls with matched age and gender were recruited into the AD group. Twenty-three MTLE patients and 28 healthy controls with matched age and gender were recruited into the MTLE group. All subjects were scanned on 3T-MRI scanner. Automated volumetric analysis was applied to measure and compare the hippocampal volume of the two respective groups. Vertex-based morphologic analysis was applied to characterize the morphologic patterns of hippocampal atrophy within and between groups, and a correlation analysis was performed. Results: Volumetric analysis revealed significantly decreased hippocampal volume in both AD and MTLE patients compared to the controls. In the patients with AD, the mean total hippocampal volume was 32.70% smaller than that of healthy controls, without a significant difference between the left and the right hippocampus ( p & 0.05). In patients with MTLE, a significant reduction in unilateral hippocampal volume was observed, with a mean volume reduction of 28.38% as compared with healthy controls ( p & 0.05). Vertex-based morphologic analysis revealed a generalized shrinkage of the hippocampi in AD patients, especially in bilateral medial and lateral regions. In MTLE group, atrophy was seen in the ipsilateral head, ipsilateral lateral body and slightly contralateral tail of the hippocampus (FWE-corrected, p & 0.05). Conclusions: MTLE and AD have distinctive morphologic patterns of hippocampal atrophy, which provide new insight into the radiology-pathology correlation in these diseases.
机译：目的：患有颞叶癫痫（咒语）和阿尔茨海默病（AD）是与海马萎缩相关的两个不同的神经障碍。我们的目标是分析海马萎缩的形态学模式，以更好地了解两个条件的潜在病理和临床特征。方法：招募了二十五名具有匹配年龄和性别的AD和20名健康对照，被招募到广告组中。招募了二十三名咒语患者和28名健康对照，招募进入莫尔群组。所有受试者均在3T-MRI扫描仪上扫描。应用自动体积分析来测量和比较两组的海马体积。基于顶点的形态学分析用于表征在组内和之间的海马萎缩的形态图案，并进行相关分析。结果：与对照组相比，体积分析显示，广告和咒语患者的海马体积显着降低。在AD的患者中，平均总海马体积比健康对照的32.70％小，而左侧和右海马之间没有显着差异（P <0.05）。在咒语患者中，观察到单侧海马体积显着降低，与健康对照相比，平均体积减少28.38％（P <0.05）。基于Vertex的形态学分析揭示了AD患者中海马的广义收缩，特别是在双侧内侧和侧面区域。在咒语组中，萎缩在同侧头部，同侧侧身和海马略微对侧尾观察（FWE校正，P <0.05）。结论：咒语和广告具有独特的海马萎缩形态模式，这为这些疾病的放射病理学相关性提供了新的洞察力。

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