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Expression and clinical significance of p62 protein in colon cancer

机译：P62蛋白在结肠癌中的表达及临床意义

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p62 is a multifunctional protein involved in multiple cellular processes including proliferation, drug sensitivity and autophagy-associated cancer cell growth. However, the role of p62 in colon cancer remains controversial. Here we investigated the expression of p62 protein in colon cancer and its clinical significance. Patients with colon adenocarcinoma who underwent resection at the Third Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital) were retrospectively analyzed. The expression of p62 protein in tumor tissues and adjacent normal tissues was detected by immunohistochemistry and western-blotting. Real-time quantitative polymerase chain reaction was used to detect the expression level of p62 messenger ribonucleic acid in specimens. Progression-free survival (PFS) and overall survival (OS) were assessed using Kaplan-Meier method and the log-rank test. A total of 85 colon cancer patients were enrolled, including 55 (64.71%) patients with high p62 expression, and 30 (35.29%) patients with low p62 expression. The transcription and expression level of p62 in colon cancer tissues were higher than those in adjacent normal tissues ( P .01). High expression of p62 was an independent risk factor for the poor prognosis (PFS and OS) of colon cancer . p62 may be a potential indicator of determining the progression and prognosis evaluation of colon cancer .
机译：P62是涉及多种细胞过程的多功能蛋白，包括增殖，药物敏感性和自噬相关的癌细胞生长。然而，P62在结肠癌中的作用仍然存在争议。在这里，我们研究了结肠癌P62蛋白的表达及其临床意义。回顾性分析了在新疆医科大学（附属癌症医院）第三附属教学医院接受切除的结肠腺癌患者。免疫组织化学和蛋白质检测到肿瘤组织中p62蛋白和相邻正常组织的表达。实时定量聚合酶链反应检测样品中P62信使核糖核酸的表达水平。使用Kaplan-Meier方法和日志秩检验评估无进展生存期（PFS）和总体存活（OS）。共有85例结肠癌患者，包括55例（64.71％）高p62表达患者，30例（35.29％）患者低p62表达。结肠癌组织中P62的转录和表达水平高于相邻正常组织中的转录和表达水平（P <.01）。 P62的高表达是结肠癌预后差（PFS和OS）的独立危险因素。 P62可以是确定结肠癌进展和预后评估的潜在指标。

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