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Photoacoustic treatment mitigates cognitive dysfunction in a model of sleep-wake rhythm disturbance

机译：光声治疗减轻了睡眠节奏扰动模型中的认知功能障碍

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Sleep-wake rhythm disturbances, which are characterized by abnormal sleep timing or duration, are associated with cognitive dysfunction. Photoacoustic treatments including light and sound stimulation have been found to be effective in modulating sleep patterns and improving cognitive behavior in abnormal sleep-wake pattern experiments. In this study, we examined whether light and sound interventions could reduce sleep-wake pattern disturbances and memory deficits in a sleep rhythm disturbance model. We established a model of sleep rhythm disturbance in C57BL/6J mice via a sleep deprivation method involving manual cage tapping, cage jostling, and nest disturbance. We used a Mini Mitter radio transmitter device to monitor motor activity in the mice and fear conditioning tests to assess cognitive function. Our results indicated that an intervention in which the mice were exposed to blue light (40-Hz flickering frequency) for 1 hour during their subjective daytime significantly improved the 24-hour-acrophase shift and reduced the degree of memory deficit induced by sleep deprivation. However, interventions in which the mice were exposed to a 40-Hz blue light at offset time or subjective night time points, as well as 2 Hz-blue light at 3 intervention time points (subjective day time, subjective night time, and offset time points), had no positive effects on circadian rhythm shift or memory deficits. Additionally, a 2000-Hz sound intervention during subjective day time attenuated the 24-hour-acrophase shift and memory decline, while 440-Hz and 4000-Hz sounds had no effect on circadian rhythms. Overall, these results demonstrate that photoacoustic treatment effectively corrected abnormal sleep-wake patterns and cognitive dysfunction associated with sleep-deprivation-induced disturbances in sleep-wake rhythm. All animal experiments were approved by the Experimental Animal Ethics Committee of Drum Tower Hospital Affiliated to the Medical College of Nanjing University, China (approval No. 20171102) on November 20, 2017.
机译：睡眠唤醒节奏扰动，其特征在于睡眠定时或持续时间，与认知功能障碍有关。已经发现包括光和声刺激的光声处理在调节睡眠模式和改善异常睡眠模式实验中的认知行为以及改善认知行为。在这项研究中，我们检查了光线和声音干预是否可以减少睡眠节奏扰动模型中的睡眠唤醒模式扰动和记忆缺陷。我们通过涉及手动笼式攻丝，笼子开始和巢扰动的睡眠剥夺方法在C57BL / 6J小鼠中建立了睡眠节律扰动模型。我们使用了一个迷你混搭无线电发射器设备来监测小鼠的电机活动，并担心调节测试以评估认知功能。我们的研究结果表明，在其主观白天在其主观白昼期间将小鼠暴露于蓝光（40-Hz闪烁频率）的干预，显着提高了24小时静态基团移位，并降低了睡眠剥夺诱导的记忆缺陷程度。然而，在偏移时间或主观夜间时间点，在3个干预时间点（主观日期，主观夜间和偏移时间，将小鼠暴露于40赫兹蓝光的干预措施，其中小鼠在偏移时间或主体夜间时间点，以及2 Hz-Blue灯要点），对昼夜节律转移或记忆赤字没有积极影响。此外，在主观日期期间的2000-Hz声音干预减弱了24小时静态的换档和记忆下降，而440 Hz和4000 Hz声音对昼夜节律没有影响。总体而言，这些结果表明，光声治疗有效地纠正了与睡眠唤醒节奏中睡眠剥夺诱导的休眠相关的异常睡眠模式和认知功能障碍。 2017年11月20日，所有动物实验均经过南京大学医学院隶属于南京大学院长医院的实验动物伦理委员会批准。

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