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首页> 外文期刊>Nutrition Journal >Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial
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Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial

机译：肉桂补充对2型糖尿病患者的全身炎症因子，NF-KB和SIRTUIN-1（SIRT1）表达的影响：随机，双盲和对照临床试验

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BACKGROUND AND OBJECTIVES:NF-kB, SIRT1 and systemic inflammation factors including hs-CRP, IL-6 and TNF-α accelerate atherosclerosis pathogenesis. Our purpose was to evaluate the effect of daily supplementation of three-gram cinnamon on plasma levels of NF-kB, SIRT, hs-CRP, IL-6 and TNF-α among type 2 diabetes patients.SUBJECTS AND METHODS:A randomized, double blind, and controlled clinical trial was performed with 44 adult patients who were 25 to 70?years old with type 2 diabetes, randomized to two intervention (n?=?22) and control (n?=?22) groups differing by daily three grams cinnamon supplementation and placebo for 8?weeks, respectively. The plasma levels of NF-kB, SIRT, hs-CRP, IL-6 and TNF-α were measured by ELISA assay at the beginning and end of the study.RESULTS:After 8-week intervention, 39 subjects (n?=?20 in the cinnamon and n?=?19 in the placebo groups) ended up the trial. It was not observed significant difference in levels of hs-CRP (P?=?0.29), TNF-α (P?=?0.27), IL-6 (P?=?0.52), and Sirtuin-1 (P?=?0.51) in between group comparison. While, the result showed significant difference in levels of NF-kB (P?=?0.02) between groups. As well as, in among group comparison, there was not observed significant differences except in hs-CRP (P?=?0.008) in placebo group.CONCLUSIONS:This study elucidated that cinnamon supplementation has no beneficial effects in reduction of NF-kB, SIRT1, hs-CRP, IL-6 and TNF-α levels in type 2 diabetes patients which have a considerable role in development of atherogenesis.
机译：背景和目标：NF-KB，SIRT1和全身炎症因子，包括HS-CRP，IL-6和TNF-α加速动脉粥样硬化发病机制。我们的目的是评估每日补充三克肉桂在2型糖尿病患者中NF-KB，SIRT，HS-CRP，IL-6和TNF-α的血浆水平的效果。 - 抽取和方法：随机，双重盲目和受控临床试验用44名成年患者进行25至70岁？岁月，患有2型糖尿病，随机分为两个干预（n？=？22），并控制（n？= 22）群体不同的三个克分别克肉桂补充剂和安慰剂8？周。通过ELISA测定在研究开始和结束时测量NF-KB，SIRT，HS-CRP，IL-6和TNF-α的血浆水平。结果：8周干预后，39个受试者（n？=？ 20在肉桂和n？=？19在安慰剂组中）结束了试验。它没有观察到HS-CRP水平的显着差异（p？= 0.29），TNF-α（p？= 0.27），IL-6（P？= 0.52）和Sirtuin-1（P？= ？0.51）在组比较之间。虽然，结果表明在组之间的NF-KB水平（P？= 0.02）的显着差异。除了群体比较之外，除了HS-CRP（p？= 0.008）中没有观察到安慰剂组的显着差异。结论：本研究阐明了肉桂补充剂对NF-KB的减少没有有益的影响， 2型糖尿病患者的SIRT1，HS-CRP，IL-6和TNF-α水平在血液发生发展中具有相当大的作用。

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