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首页> 外文期刊>Reports of Biochemistry and Molecular Biology >Comparison of Serum Levels of Fructosamine and Erythrocyte Sodium Potassium ATPase (Na+/K+ ATPase) in Gestational Diabetes Mellitus (GDM) and non-Gestational Diabetes Mellitus (non GDM) Patients
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Comparison of Serum Levels of Fructosamine and Erythrocyte Sodium Potassium ATPase (Na+/K+ ATPase) in Gestational Diabetes Mellitus (GDM) and non-Gestational Diabetes Mellitus (non GDM) Patients

机译：妊娠期糖尿病（GDM）和非妊娠期糖尿病（非GDM）患者果皮胺和红细胞钠钾（Na + / K + AtP酶）血清水平的比较

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Background: The study aims at the comparison and correlation of serum levels of fructosamine anderythrocyte Na+/ K+ ATPase in Gestational diabetes mellitus (GDM) and Non Gestational Diabetes Mellitus(Non GDM).Methods:A total of 326 samples were divided into 4 groups. Pregnant women between the age group of 20-40 years who gave samples for Oral Glucose Tolerance Test (OGTT) were included as the subjects.Anonymized and left over fasting and 2 hours’samples were collected from biochemistry laboratory, KasturbaHospital, Manipal.Results: In the comparison of fructosamine levels in GDM and Non GDM, fructosamine was found to besignificant (p value0.001) in both fasting and 2 hours (G2) blood glucose condition. Na+/ K+ ATPase did notshow any significant variation between the groups. Correlation was not significant between the parameters.Conclusions: Fructosamine showed significant increase when compared between the groups, whereas significantcorrelation is not obtained between the parameters. Thus, the use fructosamine as a diagnosis tool becomesinconclusive. Further studies must be carried out to identify a marker which reduces the interferences observed infructosamine and to find out the exact relationship between hyperglycaemia and Na+/ K+ ATPase activity.
机译：背景：该研究旨在对妊娠期糖尿病（GDM）和非妊娠期糖尿病（非GDM）的果皮胺和Nathrocyte Na + / K + AtP酶的血清水平的比较和相关性。方法：将326个样品分成4组。将孕妇在20-40岁之间给予口腔葡萄糖耐量试验（OGTT）的年龄组之间作为主题。匿名和留在禁食中，从生物化学实验室，Kasturbahospital，Manipal.Results收集了2小时的血统，结果：在GDM和非GDM中的果糖胺水平的比较中，发现果胺胺在禁食和2小时（G2）血糖条件下都是在禁食中的（P值<0.001）。 Na + / K + ATP酶在组之间做出了任何显着的变化。参数之间的相关性并不重要。结论：在组之间比较时果胺显示出显着增加，而在参数之间无法获得显着性核制性。因此，使用果糖胺作为诊断工具变得亮。必须进行进一步的研究以鉴定减少观察到的infuctosamine的干扰并找出高血糖和Na + / k + ATP酶活性的确切关系。

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