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Effects of Dimethylaminoethanol and Compound Amino Acid on D-Galactose Induced Skin Aging Model of Rat

机译:二甲基氨基乙醇和化合物氨基酸对大鼠D-半乳糖诱导皮肤老化模型的影响

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A lasting dream of human beings is to reverse or postpone aging. In this study, dimethylaminoethanol (DMAE) and compound amino acid (AA) in Mesotherapy were investigated for their potential antiaging effects on D-galactose induced aging skin. At 18 days after D-gal induction, each rat was treated with intradermal microinjection of saline, AA, 0.1% DMAE, 0.2% DMAE, 0.1% DMAE + AA, or 0.2% DMAE + AA, respectively. At 42 days after treatment, the skin wound was harvested and assayed. Measurement of epidermal and dermal thickness in 0.1% DMAE + AA and 0.2% DMAE + AA groups appeared significantly thicker than aging control rats. No differences were found in tissue water content among groups. Hydroxyproline in 0.1% DMAE + AA, 0.2% DMAE + AA, and sham control groups was much higher than all other groups. Collagen type I, type III, and MMP-1 expression was highly upregulated in both 0.1% DMAE + AA and 0.2% DMAE + AA groups compared with aging control. In contrast, TIMP-1 expression levels of various aging groups were significantly reduced when compared to sham control. Coinjection of DMAE and AA into target tissue has marked antiaging effects on D-galactose induced skin aging model of rat.
机译:持久的人类梦想是逆转或推迟老化。在该研究中,研究了乳腺癌中的二甲基氨基乙醇(DMAE)和化合物氨基酸(AA),以对D-半乳糖诱导的老化皮肤潜在的抗衰老作用。在D-GAL诱导后18天,每只大鼠用皮甲菌,AA,0.1%DMAE,0.2%DMAE,0.1%DMAE + AA或0.2%DMAE + AA的皮内部分别处理。治疗后42天,收获皮肤伤口并测定。 0.1%DMAE + AA和0.2%DMAE + AA基团的表皮和皮肤厚度的测量显着厚于老化对照大鼠。组织水含量没有发现差异。羟脯氨酸在0.1%DMAE + AA,0.2%DMAE + AA和假对照组中高于所有其他组。与老化对照相比,胶原蛋白I型,III型和MMP-1表达高度上调,在0.1%DMAE + AA和0.2%DMAE + AA组中高度上调。相反,与假对照相比,各种老化基团的TIMP-1表达水平显着降低。 DMAE和AA中的标记为靶组织对D-半乳糖诱导的大鼠皮肤衰老模型具有明显的抗衰老作用。

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