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首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Beneficial effects of branched-chain amino acids on altered protein and amino acid metabolism in liver cirrhosis: evaluation in a model of liver cirrhosis induced in rats with carbon tetrachloride.
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Beneficial effects of branched-chain amino acids on altered protein and amino acid metabolism in liver cirrhosis: evaluation in a model of liver cirrhosis induced in rats with carbon tetrachloride.

机译：支链氨基酸对肝硬化大鼠蛋白质和氨基酸代谢改变的有益影响：在四氯化碳大鼠肝硬化模型中的评估。

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摘要

The effect of branched-chain amino acids (BCAA) on the metabolism of protein, amino acids and ammonia was examined in rats with cirrhosis, with a special emphasis on the efficacy of early administration of BCAA. Liver cirrhosis was induced in rats by intraperitoneal injections of carbon tetrachloride (CCl(4)). The rats were divided into three groups: early-, late- and untreated. The early- and late-treated groups were given BCAA rich food from the early and late stage of liver cirrhosis, while the untreated group was given standard food throughout. Concentrations of amino acids and ammonia in the plasma and the ornithine carbamyl transferase (OCT) activity in the liver were evaluated, and compared with control group after 15 weeks maintenance. Ammonia was significantly higher in the late- and untreated groups, but not in the early-treated group. BCAA, tyrosine, and methionine were significantly lower in the untreated and late-treated groups. Glutamine increased significantly in the un-, late- and early-treated groups. However, no significant differences were found among three groups. A significant difference was found in 3-methyl histidine (3-MH) between the early- and late-treated groups. This study suggests that the administration of BCAA from early stage of liver cirrhosis inhibits breakdown of protein and improves metabolism of protein, amino acids and ammonia.
机译：在肝硬化大鼠中检查了支链氨基酸（BCAA）对蛋白质，氨基酸和氨代谢的影响，特别着重于早期给予BCAA的功效。腹腔内注射四氯化碳（CCl（4））诱导大鼠肝硬化。将大鼠分为三组：早期，晚期和未治疗。早期和晚期治疗组在肝硬化的早期和晚期都给予富含BCAA的食物，而未治疗组则始终给予标准食物。评估血浆中氨基酸和氨的浓度以及肝脏中鸟氨酸氨基甲酰基转移酶（OCT）的活性，并在维持15周后与对照组进行比较。晚期和未治疗组的氨水平明显升高，但早期治疗组未升高。在未治疗和晚期治疗组中，BCAA，酪氨酸和蛋氨酸显着降低。未治疗，晚期和早期治疗组的谷氨酰胺明显增加。但是，三组之间没有发现显着差异。早期治疗组和晚期治疗组之间的3-甲基组氨酸（3-MH）存在显着差异。这项研究表明，从肝硬化早期开始服用BCAA可以抑制蛋白质分解，并改善蛋白质，氨基酸和氨的代谢。

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