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首页> 外文期刊>Systematic Reviews >Local infiltration of tramadol as an effective strategy to reduce post-operative pain: a systematic review protocol and meta-analysis
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Local infiltration of tramadol as an effective strategy to reduce post-operative pain: a systematic review protocol and meta-analysis

机译：靶曲马多的局部浸润是减少术后疼痛的有效策略：系统审查方案和荟萃分析

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The purpose of this review is to evaluate the use and effectiveness of the local administration of tramadol in reducing post-operative pain during surgical interventions. The PubMed, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) databases will be searched for this review. This systematic review will include studies evaluating the clinical efficacy of the local infiltration of tramadol, with no study design restrictions. Only studies that present clear descriptions of local tramadol administration are published in peer-reviewed journals in the English, Italian, Spanish, French, Portuguese or German language and are published in full will be taken into consideration. A meta-analysis will be performed when there is sufficient clinical homogeneity among the retrieved studies, and only randomized controlled studies and quasi-randomized controlled studies will be included. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used to assess the certainty in the evidence. If a quantitative analysis cannot be conducted, a qualitative description of the results of the retrieved studies will be provided. A high-quality synthesis of the current evidence on the local administration of tramadol for managing post-surgical pain will be illustrated using subjective reports and objective measures of performance. The primary outcomes will include the magnitude of post-operative pain intensity improvement, with improvement being as defined by a reduction by at least 2 points in the visual analogue scale (VAS) score or numerical rating scale (NRS) score. The secondary outcomes will be the magnitude of reduction in tramadol rescue doses and in other analgesic drug doses. This protocol will present evidence on the efficacy of tramadol in relieving post-surgical pain.
机译：本综述的目的是评估靶曲马多的使用和有效性在手术干预期间减少手术后疼痛。将搜索受控试验的PubMed，Embase和Cochrane中央登记册（中央）数据库，以获取此评论。这种系统审查将包括评估曲马多的局部浸润的临床疗效，没有研究设计限制。只有在对当地曲马多的情况下发表明确描述的研究，在同行评审的英语，意大利语，西班牙语，法国，葡萄牙语或德语或德语的期刊上发表，并以完全发表的方式。当检索研究中存在足够的临床同质性时，将进行META分析，并且仅包括随机对照研究和准随机对照研究。建议评估，发展和评估（等级）方法的评分将用于评估证据中的确定性。如果不能进行定量分析，将提供对检索研究结果的定性描述。利用主观报告和客观的绩效衡量，将说明关于用于管理手术后痛苦的靶曲马多的当前证据的高质量合成。主要结果将包括后术后疼痛强度改善的幅度，改善，如视觉模拟量表（VAS）得分或数值评级（NRS）得分中的至少2分。二次结果将是曲马多的减少症状剂量和其他镇痛药剂量的程度。该议定书将提出有关曲马多效果缓解手术后疼痛的疗效的证据。

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