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Serological profile of hepatitis B in children after the introduction of its vaccination in Burkina Faso

机译：在Burkina Faso引入疫苗接种后儿童乙型肝炎的血清学谱

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Viral hepatitis B is a public health issue. We establish the children serological profile of hepatitis B in Bobo-Dioulasso, six years after the introduction of hepatitis B vaccine into the Expanded Program on Immunization. This was a descriptive study of prospective data collection carried out in the Department of Pediatrics and the laboratory of virology of the Centre MURAZ of Bobo-Dioulasso between March 2013 and May 2013. Blood samples were made in search of the following hepatitis B serological markers: anti-HBcAb total, HBsAg, Ac anti-HBs, HBeAg, AcHBs, IgM anti-HBc total. The ELISA method with the Monolisa BIORAD reagents was used. A total of 2015 children were included, 1026 (50, 9%) boys and 989 (49.1%) girls, at an average age of 58±48 months. Out of these 2015 children, 53 (2.6%) were positive to HBsAg including 19 vaccinated cases, one child has received 3 doses plus 1 booster dose of hepatitis B vaccine. We found no statistically significant difference in the carriage of serologic markers of hepatitis B between the unvaccinated group and the vaccinated group. Large-scale studies should be carried out in Burkina Faso to see the real impact of vaccination on the health of our populations.
机译：病毒性乙型肝炎是一个公共卫生问题。我们建立了乙型肝炎乙型肝炎乙型肝炎的儿童血清学曲线，六年后在引入乙型肝炎疫苗进入免疫扩大计划。这是在2013年3月至2013年3月在2013年3月至2013年5月间在儿科和博博市中心村庄中央村庄Virology的实验室进行了描述性研究。采用血液样本寻找以下乙型肝炎血清学标志：抗HBCAB总，HBsAg，AC抗HBS，HBEAG，ACH，IgM抗HBC总数。使用了具有单溶胶生物试剂的ELISA方法。共有2015年的儿童，1026名（50,9％）男孩和989名（49.1％）女孩，平均年龄为58±48个月。在这些2015年的儿童中，53名（2.6％）对HBsAg呈阳性，包括19个疫苗案例，一个孩子已接受3剂加1剂量的乙型肝炎疫苗。我们发现未接种催化组和疫苗基团之间的乙型肝炎血清症状血清素标志物的血清素标志物的血管血清标记没有统计学意义。大规模研究应在布基纳法索进行，看看疫苗接种对人口健康的实际影响。

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