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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats
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Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats

机译：爬行动物对大鼠脂多糖诱导的记忆障碍的抑制作用

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Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but it has also been shown to exhibit strong antioxidative, anti-inflammatory, and neuroprotective effects. Here, we sought to investigate the effects of CAR on inflammation in the hippocampus and prefrontal cortex, as well as the molecular mechanisms underlying these effects. In our study, lipopolysaccharide was injected into the lateral ventricle of rats to induce memory impairment and neuroinflammation. Daily administration of CAR (25, 50, and 100 mg/kg) for 21 days improved recognition, discrimination, and memory impairments relative to untreated controls. CAR administration significantly attenuated expression of several inflammatory factors in the brain, including interleukin-1β, tumor necrosis factor-α, and cyclooxygenase-2. In addition, CAR significantly increased expression of brain-derived neurotrophic factor (BDNF) mRNA, and decreased expression of Toll-like receptor 4 (TLR4) mRNA. Taken together, these results show that CAR can improve memory impairment caused by neuroinflammation. This cognitive enhancement is due to the anti-inflammatory effects of CAR medicated by its regulation of BDNF and TLR4. Thus, CAR has significant potential as an inhibitor of memory degeneration in neurodegenerative diseases.
机译：神经炎性是各种神经变性疾病的重要过程。 Carvacrol（汽车）是一种酚醛单萜烯，常用作为食品添加剂，由于其抗菌性能，但也已被证明表现出强烈的抗氧化，抗炎和神经保护作用。在这里，我们试图探讨汽车对海马和前额叶皮质炎症的影响，以及这些效果的分子机制。在我们的研究中，脂多糖注入大鼠的侧心脑室以诱导记忆障碍和神经炎症。每日施用汽车（25,50和100 mg / kg）21天改善了相对于未处理对照的识别，歧视和记忆障碍。汽车管理局显着减弱了大脑中几种炎症因素的表达，包括白细胞介素-1β，肿瘤坏死因子-α和环氧氧酶-2。此外，汽车显着增加了脑衍生的神经营养因子（BDNF）mRNA的表达，并降低了Toll样受体4（TLR4）mRNA的表达。总之，这些结果表明，汽车可以提高神经引起的炎症造成的记忆障碍。这种认知增强是由于轿厢对BDNF和TLR4调节的抗炎作用。因此，汽车具有作为神经变性疾病中记忆变性的抑制剂具有显着潜力。

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