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首页> 外文期刊>The Open Anesthesia Journal >Intraoperative Dexmedetomidine has no Effect on Postoperative Pain Scores for Posterior Spinal Fusion
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Intraoperative Dexmedetomidine has no Effect on Postoperative Pain Scores for Posterior Spinal Fusion

机译：术中的Dexmedetomidine对后脊椎融合的术后疼痛评分没有影响

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Background:Posterior Spinal Fusion (PSF) for idiopathic scoliosis results in severe postoperative pain. At our institution, a protocol for postoperative analgesia is followed, but anesthetic maintenance is decided by the anesthesiologist. Previous studies have shown that postoperative use of dexmedetomidine may improve analgesia for these patients, but the effect of intraoperative dexmedetomidine on postoperative pain scores remains unknown.Purpose:We sought to retrospectively compare pain scores from the Postoperative Anesthesia Care Unit (PACU) and from PACU discharge until midnight between PSF patients who did and did not receive intraoperative dexmedetomidine.Methods:After obtaining IRB approval, we retrospectively identified 79 patients aged 10-17 years who had undergone PSF for idiopathic scoliosis from June 2015-August 2018 and who received intrathecal morphine. Patients were then divided into two groups based on whether or not they received intraoperative dexmedetomidine. A multivariable linear regression model was constructed with the dependent variable of highest PACU pain score and exposure of interest intraoperative dexmedetomidine use. Secondary analyses were conducted similarly within those who received dexmedetomidine to examine the effects of dose on PACU pain scores, using a p-value < 0.05.Results:After adjusting for age, weight, sex, levels fused, intrathecal morphine, diazepam, and ketamine doses, there was no statistically significant difference in average PACU pain scores between those who did and did not receive intraoperative dexmedetomidine (β = -0.85, 95% CI: -2.48, 0.68; p = 0.31).Conclusion:Intraoperative use of dexmedetomidine during posterior spinal fusion for adolescent idiopathic scoliosis appears to have no effect on postoperative pain scores.
机译：背景：特发性脊柱侧凸的后脊柱融合（PSF）导致严重的术后疼痛。在我们的机构，遵循术后镇痛的议定书，但麻醉师决定麻醉师。以前的研究表明，Dexmedetomidine的术后可以改善这些患者的镇痛，但术后德克梅哌咪唑对术后疼痛评分的影响仍然不明.Purpose：我们试图回顾性地比较术后麻醉护理单元（PACU）和PACU的疼痛评分排放到患有术中没有接受的PSF患者之间的午夜。方法：在获得IRB批准后，我们​​回顾性地确定了79名10-17岁的患者，从2015年6月至2018年8月到2015年8月的特发性脊柱侧凸患者进行了患者，并且接受了鞘内调味术治疗。然后根据它们是否接受术中的右甲酰嘌呤胺，分为两组患者。多变量的线性回归模型由最高PACU疼痛评分的依赖变量和术术中的暴露术术中的探测剂。在接受Dexmedetomidine的那些人内进行二次分析，以检查剂量对PACU疼痛评分的影响，使用p值<0.05.结果：调整年龄，体重，性别，水平融合，鞘内吗啡，二氮泮和氯胺酮剂量，没有统计学上显着的差异，平均疼痛评分在那些并且没有接受术中脱氧嘌呤（β= -0.85,95％Ci：-2.48,0.68; p = 0.31）。结论：术中使用德克梅哌咪啶期间对青少年特发性脊柱侧凸的后脊柱融合似乎对术后疼痛评分没有影响。

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