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Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer

机译：淋巴结检查的影响依靠切除食管癌的准确分期和存活

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We examined the association between numbers of lymph nodes examined (LNEs) and accurate staging and survival to determine the optimal LNE count during esophagectomy using data from the Surveillance, Epidemiology, and End Results (SEER) cancer registry and the Department of Thoracic Surgery of a single institution (SI). A total of 7356 EC patients met our inclusion criteria from the SEER database and 1275 patients from SI. We applied multivariate models to investigate the relationship between the LNE count and LN metastasis and cancer-specific survival (CSS). Odds ratios (ORs) and hazard ratios (HRs) generated by the multivariate models were fitted with Locally Weighted Scatterplot?Smoothing, and the structural breakpoints were determined by the Chow test. Higher numbers of LNEs were linked to a higher proportion of LN metastasis and better CSS in both cohorts. Cut-point analysis determined a threshold of LNEs of 12 for adenocarcinoma and 14 for esophageal squamous cell cancer (ESCC) considering accurate staging, and 15 for adenocarcinoma and 14 for ESCC considering OS. The cut-points for CSS were examined in the SEER database and validated in the divided cohort from SI (all P??0.05). A greater number of LNEs are significantly associated with more accurate N staging and better survival in EC patients. We recommend 15 and 14 as the threshold LNE counts for adenocarcinoma and ESCC patients, respectively. ? 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.
机译：我们检查了淋巴结数之间的关系（LNES）和准确的分期和存活，使用来自监测，流行病学和最终结果（SEER）癌症登记处的数据和A的胸部手术部和A的胸部手术部来确定食道切除术期间的最佳LNE计数。单一机构（SI）。共有7356名EC患者从Seer数据库和来自SI的1275名患者达到了我们的纳入标准。我们应用多变量模型来研究LNE计数和LN转移与癌症特异性生存（CSS）之间的关系。由多变量模型产生的大量比率（ORS）和危险比（HRS）配有局部加权的散射片？平滑，并且通过CHOW试验确定结构断点。较高数量的LNE与较高比例的LN转移和两个群组中的CSS相连。截止点分析确定了腺癌的损伤的阈值，用于腺癌和14用于对食管鳞状细胞癌（ESCC）考虑准确分期，以及用于考虑操作系统的ESCC的腺癌和14。在SEER数据库中检查了CSS的切割点，并在SI的分开的群组中验证（所有P？<？0.05）。较多人的LNE与EC患者的更准确的N分期和更好的存活率显着相关。我们推荐15和14作为腺癌和ESCC患者的阈值LNE计数。 ？ 2019年的作者。中国肺部肿瘤集团和约翰瓦里和儿子澳大利亚发表的胸癌

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