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Bioinformatics analysis of LINC00426 expression in lung cancer and its correlation with patients' prognosis

机译：LINC00426在肺癌中表达的生物信息分析及其与患者预后的相关性

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BACKGROUND:To investigate the expression of long noncoding RNA (lncRNA) LINC00426 (long intergenic nonprotein coding RNA 426) in non-small cell lung cancer (NSCLC) patients and its correlation with their prognosis.METHODS:The expression of long noncoding RNA LINC00426 of non-small cell lung cancer (NSCLC) in The Cancer Genome Atlas (TCGA) database was screened. According to the expression level of LINC00426 in tumor tissue of NSCLC patients, the patients were divided into high and low LINC00426 expression groups. The correlation between LINC00426 expression group and the prognosis of the patient was analyzed by log-rank test. A total of 72 NSCLC patients who had undergone surgery were retrospectively included in this study. LINC00426 relative expression of tumor and normal lung tissue of the included 72 NSCLC patients were examined by real-time quantitative PCR assay. The correlation between LINC00426 expression and the patients' clinical characteristics were also evaluated.RESULTS:LINC00426 relative expression was not statistically different between cancer and normal tissue (P??0.05) of NSCLC patients in the TCGA database. The amplification and deep deletion mutation of LINC00426 gene was found in 0.5% of NSCLC patients. The overall survival (OS) of the LINC00426 high expression group was significantly higher than that of the low expression group (HR = 0.81, P = 0.044), while there was no significant difference between the high and low expression group (HR = 0.97, P = 0.82) for disease-free survival (DFS). LINC0042646 expression level was elevated in 46 cases in normal lung tissue compared to the tumor tissue of the 72 NSCLC patients. LINC0042646 expression level was significantly correlated with the clinical stage (P??0.05).CONCLUSION:Long noncoding RNA LINC00426 was downregulated in the tumor tissue of NSCLC patients and correlated with poor prognosis.? 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.
机译：背景：探讨在非小细胞肺癌（NSCLC）患者中的长非分量RNA（LNCRANA）LINC00426（LONG CONCRETEIN编码RNA 426）的表达及其与预后的相关性。方法：长度非致rna linc00426的表达筛选癌症基因组Atlas（TCGA）数据库中的非小细胞肺癌（NSCLC）。根据NSCLC患者肿瘤组织的LINC00426的表达水平，患者分为高低水00426表达组。通过对数秩检验分析LINC00426表达组和患者预后的相关性。在本研究中回顾性地纳入了经历过手术的72名NSCLC患者。 LINC00426通过实时定量PCR测定检查包含的72个NSCLC患者的肿瘤和正常肺组织的相对表达。还评估了LINC00426表达与患者临床特征的相关性。结果：LINC00426相关表达在TCGA数据库中的NSCLC患者的NSCLC患者（P？> 0.05）之间没有统计学不同。在0.5％的NSCLC患者中发现了LINC00426基因的扩增和深缺失突变。 LINC00426高表达组的整体存活率显着高于低表达组（HR = 0.81，P = 0.044），而高表达组无显着差异（HR = 0.97， p = 0.82）无疾病存活（DFS）。与72个NSCLC患者的肿瘤组织相比，LINC0042646表达水平升高了正常肺组织中的46例。 LINC0042646表达水平与临床阶段显着相关（P？<？0.05）。结论：长时间的NOODING RNA LINC00426在NSCLC患者的肿瘤组织中下调，并与预后差相关。？ 2019年的作者。中国肺部肿瘤集团和约翰瓦里和儿子澳大利亚发表的胸癌

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