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首页> 外文期刊>Therapeutic advances in medical oncology. >Treatment effects of cumulative cisplatin dose during radiotherapy following induction chemotherapy in nasopharyngeal carcinoma: propensity score analyses
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Treatment effects of cumulative cisplatin dose during radiotherapy following induction chemotherapy in nasopharyngeal carcinoma: propensity score analyses

机译：鼻咽癌诱导化疗后放射治疗累积顺铂剂量的治疗效果：倾向分数分析

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Background: The treatment effects of cumulative cisplatin dose (CCD) during radiotherapy (RT) following induction chemotherapy (IC) have not been determined for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). Methods: A total of 3460 patients with locoregionally advanced NPC who were treated with IC plus cisplatin-based concurrent chemoradiotherapy or RT alone were included in this retrospective study. Three CCD groups (0?mg/m 2 ???CCD? 2 , 100?mg/m 2 ???CCD? 2 , CCD??200?mg/m 2 ) were balanced through the inverse probability of treatment weighting based on propensity scores estimated by a general boosted model. The primary endpoint was overall survival (OS); the secondary endpoints were distant metastasis-free survival (DMFS) and locoregional recurrence-free survival (LRFS). Results: CCD??200?mg/m 2 and 2 exhibited similar treatment effects for OS and DMFS, and were both superior to CCD? 2 for OS and DMFS in patients with stage IVa NPC. The three CCD groups achieved similar treatment effects for patients with stage II–III NPC. After IC, CCD during RT appeared to exert little treatment effect on LRFS. Conclusion: The CCD during RT exerts treatment effects and improves OS by reducing the risk of distant metastasis for patients with stage IVa NPC following IC, and CCD? 2 (mainly 160?mg/m 2 in this group) is recommended. However, RT alone may be sufficient after IC in patients with stage II–III NPC.
机译：背景：放疗期间诱导化疗（IC）累积剂量的顺铂（CCD）的治疗效果（RT）尚未确定患者局部晚期鼻咽癌（NPC）。方法：共有3460例局部晚期鼻咽癌谁用IC加顺铂为主的同步放化疗或单独RT治疗被纳入本回顾性研究。三个CCD团体（0？毫克/米2＆pi; CCD？2，100？毫克/米2＆pi; CCD？2，CCD ?? 200？毫克/米2）通过治疗的逆概率是平衡的加权值基于对一般的提振模型估计倾向得分。主要终点是总生存（OS）;次级终点是无远处转移的存活（DMFS）和局部区域无复发存活（LRFS）。结果：CCD×200毫克/米2和2表现出类似的处理的OS和DMFS效果，均优于CCD？ 2操作系统和患者ⅣA期NPC的DMF。这三个CCD组实现了类似的患者治疗效果与舞台II-III NPC。 IC后，RT期间出现CCD上施加LRFS小的治疗效果。结论：RT期间，CCD发挥治疗效果，并通过减少对患者的阶段IVA NPC远处转移的下列IC，和CCD的风险提高了OS？ 2（主要是160？毫克/米2这一组中）被推荐。然而，单独RT可以IC之后就足够了患者的II期，III NPC。

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