首页> 外文期刊>Translational psychiatry. >On the diagnostic and neurobiological origins of bipolar disorder
【24h】

On the diagnostic and neurobiological origins of bipolar disorder

机译:对双相障碍的诊断和神经生物学起源

获取原文
           

摘要

Psychiatry is constructed around a taxonomy of several hundred diagnoses differentiated by nuances in the timing, co-occurrence, and severity of symptoms. Bipolar disorder (BD) is notable among these diagnoses for manic, depressive, and psychotic symptoms all being core features. Here, we trace current understanding of the neurobiological origins of BD and related diagnoses. To provide context, we begin by exploring the historical origins of psychiatric taxonomy. We then illustrate how key discoveries in pharmacology and neuroscience gave rise to a generation of neurobiological hypotheses about the origins of these disorders that facilitated therapeutic innovation but failed to explain disease pathogenesis. Lastly, we examine the extent to which genetics has succeeded in filling this void and contributing to the construction of an objective classification of psychiatric disturbance.
机译:精神病学围绕着几百个诊断的分类,在症状的时序,共同发生和严重程度中的细微差异分化。双极性障碍(BD)在这些诊断中是值得注意的,因为躁狂症,抑郁和精神病症状都是核心特征。在这里,我们追踪目前对BD和相关诊断的神经生物学起源的理解。为了提供背景,我们首先探索精神科分类的历史起源。然后,我们说明药理和神经科学中的重点发现如何产生关于这些疾病的起源的神经生物学假设,这促进了治疗创新,但未能解释疾病发病机制。最后,我们研究了遗传成功填补了这种空虚并有助于建设精神病障碍的造成贡献的程度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号