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首页> 外文期刊>Journal of Behavioral and Brain Science >A Study on the Association between Patients with Post-Traumatic Stress Disorder in Li and Han Ethnic Groups in Hainan Province and DNA Methylation of Brain-Derived Neurotrophic Factor Genes
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A Study on the Association between Patients with Post-Traumatic Stress Disorder in Li and Han Ethnic Groups in Hainan Province and DNA Methylation of Brain-Derived Neurotrophic Factor Genes

机译：海南省李和汉族后创伤后应激障碍患者与脑源神经营养因子基因的DNA甲基患者患者联系

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Objective: To explore the pathogenesis of PTSD in the brain-derived neurotrophic factor (BDNF) gene methylation of patients with posttraumatic stress disorder (Posttraumatic Stress Disorder, PTSD) in Hainan Province, the relationship between the influence of BDNF gene methylation and the influence of PTSD. Methods: A case-control study method was adopted, strictly in accordance with DSM-IV and PTSD diagnosis, and 150 Li PTSD patients matched with gender and age of 300 Han PTSD patients were selected as the research objects. The peripheral venous whole blood of the subjects was drawn, genomic DNA was extracted, modified with bisulfite, and directly sequenced to quantitatively detect the methylation status of the CpG island in the promoter region of brain-derived neurotrophic factor (BDNF). Results: The results showed that the methylation levels of CPGl, CPG2, CPG3, CPG4, CPG5, CPG6, CPG7, CPG9, CPGl2, CPGl3, CPGl4, CPGl5, CPGl6, CPGl7, and CPGl8 in THE BDNF promoter were significantly different between the HAN PTSD group and the Li PTSD group (P < 0.001). Conclusion: It is suggested that CPG methylation in the promoter region of BDNF gene is closely related to patients with PTSD. There is a statistical difference in the level of CpG methylation in the promoter region of BDNF gene in PTSD between Li and Han ethnic groups in Hainan Province. CpG methylation in the promoter region of BDNF gene may be used as a biomarker for the diagnosis of PTSD.
机译：目的：探讨海南省急性应激障碍（BDNF）患者脑衍生的神经营养因子（BDNF）基因甲基化的PTSD的发病机制，BDNF基因甲基化的影响与PTSD的影响。 方法：采用案例对照研究方法，严格按照DSM-IV和PTSD诊断，以及与性别和300岁的汉氏PTSD患者相匹配的150例作为研究对象。绘制受试者的外周静脉全血，提取基因组DNA，用亚硫酸氢盐修饰，并直接测序，以定量检测脑衍生的神经营养因子（BDNF）启动子区中CpG岛的甲基化状态。 结果：结果表明，BDNF启动子中，CPG1，CPG6，CPG4，CPG5，CPG6，CPG7，CPG9，CPG1，CPG1，CPG1，CPG1，CPGL6，CPG1和CPGL8的CPG1，CPG2，CPG3，CPG4，CPG9，CPG1，CPG1，CPG1和CPG1和CPGL8的甲基化水平显着不同汉族治疗组和Li PTSD组（ P <0.001）之间。 结论：建议BDNF基因启动子区中的CpG甲基化与PTSD患者密切相关。海南省李和汉族的PTNF基因启动子区的CPG甲基化水平存在统计学差异。 BDNF基因的启动子区域中的CpG甲基化可用作诊断PTSD的生物标志物。

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