...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Medicine >Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease
【24h】

Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease

机译：主动脉瓣钙助理与冠状动脉钙和末期肾病患者冠状动脉钙和炎症无关

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Aortic valve calcium (AVC) and coronary artery calcium (CAC) are common complications in end-stage renal disease (ESRD). We investigated the prognostic significance of overlapping presence of AVC and CAC, and whether AVC was associated with all-cause mortality independent of the presence of CAC in ESRD. Methods: 259 ESRD patients (median age 55 years, 67% males) undergoing cardiac computed tomography were included. Framingham risk score (FRS), presence of cardiovascular disease (CVD), statin use, nutritional status and other relevant laboratory data were determined at baseline. During follow-up for median 36 months, 44 patients died, and 68 patients underwent renal transplantation. Results: The baseline overlap presence of AVC and CAC was 37%. Multivariate regression analysis showed that FRS (odds ratio (OR) 2.25; 95% confidence interval (95% CI), 1.43–3.55) and CAC score (OR (95% CI), 2.18 (1.34–3.59)) were independent determinants of AVC. In competing-risk regression models adjusted for presence of CAC, inflammation, nutritional status, CVD, FRS and statin use, AVC remained independently associated with all-cause mortality (sub-hazard ratio (95% CI), 2.57 (1.20–5.51)). Conclusions: The overlap of AVC and CAC was 37% in this ESRD cohort. AVC was associated with increased all-cause mortality independent of presence of CAC, traditional risk factors and inflammation.
机译：背景：主动脉瓣钙（AVC）和冠状动脉钙（CAC）是末期肾病（ESRD）的常见并发症。我们研究了AVC和CAC重复存在的预后意义，以及AVC是否与ESRD中CAC的存在无关的全导致死亡。方法：259例ESRD患者（55岁，67％的男性67％的男性）包括在内的心脏计算断层扫描。在基线时确定了FRAMINGHAM风险评分（FRS），心血管疾病（CVD），汀类药物，营养状况和其他相关实验室数据。在36个月的中位后随访期间，44名患者死亡，68例患者接受肾移植。结果：AVC和CAC的基线重叠存在37％。多变量回归分析显示FRS（差距（或）2.25; 95％置信区间（95％CI），1.43-3.55）和CAC评分（或（95％CI），2.18（1.34-3.59）是独立的决定因素AVC。在调整CAC的竞争风险回归模型中，炎症，营养状况，CVD，FRS和他汀类药物使用，AVC仍然与全因死亡率（副危险比（95％CI），2.57（1.20-5.51）无关。 ）。结论：AVC和CAC的重叠在此ESRD队列中为37％。 AVC与含CAC，传统风险因素和炎症的存在无关的全因死亡率增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号