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首页> 外文期刊>Journal of Clinical Medicine >New Strategies for Rehabilitation and Pharmacological Treatment of Fatigue Syndrome in Multiple Sclerosis
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New Strategies for Rehabilitation and Pharmacological Treatment of Fatigue Syndrome in Multiple Sclerosis

机译：多发性硬化症疲劳综合征的恢复与药理治疗的新策略

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摘要

Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS), with an inflammatory demyelinating basis and a progressive course. The course of the disease is very diverse and unpredictable. Patients face many problems on a daily basis, such as problems with vision; sensory, balance, and gait disturbances; pain; muscle weakness; spasticity; tremor; urinary and fecal disorders; depression; and rapidly growing fatigue, which significantly influences quality of life among MS patients. Excessive fatigue occurs in most MS patients in all stages of this disease and is named MS-related fatigue. The crucial issue is the lack of effective treatment; therefore, this review focuses not only on the most common treatment methods, but also on additional novel therapies such as whole-body cryotherapy (WBC), functional electrical stimulation (FES), and non-invasive brain stimulation (NIBS). We also highlight the advantages and disadvantages of the most popular clinical scales used to measure fatigue. The entire understanding of the origins of MS-related fatigue may lead to the development of more effective strategies that can improve quality of life among MS patients. A literature search was performed using MEDLINE, EMBASE, and PEDro databases.
机译：多发性硬化症（MS）是中枢神经系统（CNS）最常见的自身免疫疾病，具有炎症脱髓鞘和进步课程。该疾病的过程非常多样化和不可预测。患者每天面临许多问题，如愿景的问题;感官，平衡和步态干扰;疼痛;肌肉无力;痉挛;震颤;尿和粪便疾病;沮丧;而且迅速增长的疲劳，这显着影响了MS患者的生活质量。在这种疾病的所有阶段的大多数患者中发生过度疲劳，并命名为MS相关的疲劳。至关重要的问题是缺乏有效的待遇;因此，本综述不仅关注最常见的治疗方法，还重点介绍，也集中在诸如全身冷冻疗法（WBC），功能性电刺激（FES）和非侵入性脑刺激（NIB）的额外新​​疗法。我们还突出了用于测量疲劳的最受欢迎的临床尺度的优缺点。对与MS相关疲劳的起源的全部了解可能导致开发更有效的策略，可以提高MS患者的生活质量。使用Medline，Embase和Pedro数据库进行文献搜索。

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