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首页> 外文期刊>Journal of Clinical Medicine >Comparison of Drusen Volume Assessed by Two Different OCT Devices
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Comparison of Drusen Volume Assessed by Two Different OCT Devices

机译：由两种不同OCT设备评估的德鲁森卷的比较

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To compare drusen volume between Heidelberg Spectral Domain (SD-) and Zeiss Swept-Source (SS) PlexElite Optical Coherence Tomography (OCT) determined by manual and automated segmentation methods. Thirty-two eyes of 24 patients with Age-Related Macular Degeneration (AMD) and drusen maculopathy were included. In the central 1 and 3 mm ETDRS circle drusen volumes were calculated and compared. Drusen segmentation was performed using automated manufacturer algorithms of the two OCT devices. Then, the automated segmentation was manually corrected and compared and finally analyzed using customized software. Though on SD-OCT, there was a significant difference of mean drusen volume prior to and after manual correction (mean difference: 0.0188 ± 0.0269 mm 3 , p 0.001, corr. p 0.001, correlation of r = 0.90), there was no difference found on SS-OCT (mean difference: 0.0001 ± 0.0003 mm 3 , p = 0.262, corr. p = 0.524, r = 1.0). Heidelberg-acquired mean drusen volume after manual correction was significantly different from Zeiss-acquired drusen volume after manual correction (mean difference: 0.1231 ± 0.0371 mm 3 , p 0.001, corr. p 0.001, r = 0.68). Using customized software, the difference of measurements between both devices decreased and correlation among the measurements improved (mean difference: 0.0547 ± 0.0744 mm 3 , p = 0.02, corr. p = 0.08, r = 0.937). Heidelberg SD-OCT, the Zeiss PlexElite SS-OCT, and customized software all measured significantly different drusen volumes. Therefore, devices/algorithms may not be interchangeable. Third-party customized software helps to minimize differences, which may allow a pooling of data of different devices, e.g., in multicenter trials.
机译：通过手动和自动分割方法比较海德堡谱域（SD-）和蔡司扫掠源（SS）斑克莱斯光学相干断层扫描（OCT）之间的德鲁森音量。包括24名年龄相关性黄斑变性（AMD）和博森肺病疗法的24例患者的32只眼睛。在中央1和3毫米ETDRS中，计算并比较圆圈玻璃葡萄卷。使用两个OCT设备的自动制造商算法进行德定分割。然后，手动校正和比较自动分割，最后使用定制软件进行分析。虽然在SD-OCT上，手工校正之前和后，在手动校正之前和后的平均博森体积有显着差异（平均差异：0.0188±0.0269 mm 3，P <0.001，COR。P <0.001，R = 0.90的相关性），存在在SS-OCT上没有发现差异（平均差异：0.0001±0.0003mm 3，P = 0.262，COR。P = 0.524，R = 1.0）。手工校正后手工校正后的Heidelberg获取的平均博森音量（平均差异：0.1231±0.0371 mm 3，P <0.001，COR。P <0.001，R = 0.68）。使用定制软件，两种器件之间的测量值差异降低和测量之间的相关性改善（平均差异：0.0547±0.0744 mm 3，P = 0.02，COR。P = 0.08，R = 0.937）。 Heidelberg SD-OCT，Zeiss Plexelite SS-OCT，以及定制软件，所有这些都是明显不同的博客体积。因此，设备/算法可能不可互换。第三方定制软件有助于最大限度地减少差异，这可能允许汇集不同设备的数据，例如，在多中心试验中。

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