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首页> 外文期刊>Journal of Clinical Medicine >The Effects of Longitudinal White Matter Hyperintensity Change on Cognitive Decline and Cortical Thinning over Three Years
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The Effects of Longitudinal White Matter Hyperintensity Change on Cognitive Decline and Cortical Thinning over Three Years

机译：三年来纵向白质超强度变化对认知下降和皮质稀薄的影响

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White matter hyperintensity (WMH) has been recognised as a surrogate marker of small vessel disease and is associated with cognitive impairment. We investigated the dynamic change in WMH in patients with severe WMH at baseline, and the effects of longitudinal change of WMH volume on cognitive decline and cortical thinning. Eighty-seven patients with subcortical vascular mild cognitive impairment were prospectively recruited from a single referral centre. All of the patients were followed up with annual neuropsychological tests and 3T brain magnetic resonance imaging. The WMH volume was quantified using an automated method and the cortical thickness was measured using surface-based methods. Participants were classified into WMH progression and WMH regression groups based on the delta WMH volume between the baseline and the last follow-up. To investigate the effects of longitudinal change in WMH volume on cognitive decline and cortical thinning, a linear mixed effects model was used. Seventy patients showed WMH progression and 17 showed WMH regression over a three-year period. The WMH progression group showed more rapid cortical thinning in widespread regions compared with the WMH regression group. However, the rate of cognitive decline in language, visuospatial function, memory and executive function, and general cognitive function was not different between the two groups. The results of this study indicated that WMH volume changes are dynamic and WMH progression is associated with more rapid cortical thinning.
机译：白质超强度（WMH）被认为是小血管疾病的替代标记，与认知障碍有关。我们研究了基线严重WMH患者WMH的动态变化，以及WMH体积纵向变化对认知下降和皮质稀疏的影响。从单一推荐中心均招募了八十七名皮轴血管轻度认知障碍。所有患者随访都随访年神经心理学测试和3T脑磁共振成像。使用自动化方法量化WMH体积，使用基于表面的方法测量皮质厚度。基于基线与最后一次随访之间的Delta WMH卷，参与者分为WMH进展和WMH回归组。为了探讨纵向变化在卷曲体积对认知下降和皮质稀疏的影响，使用了线性混合效果模型。七十名患者显示WMH进展，17个在三年期间显示WMH回归。与WMH回归组相比，WMH进展组在广泛的区域中显示出更快的皮质细化。然而，语言的认知率下降，探索函数，记忆力和执行功能，两组之间的一般认知函数与一般认知功能不同。本研究的结果表明，WMH体积变化是动态的，并且WMH进展与更快的皮质稀疏相关。

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