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首页> 外文期刊>Journal of Clinical Medicine Research >A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency
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A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency

机译：口服β发球菌对急性外周眩晕治疗急性外周眩晕的效果和副作用的比较

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Background: Vertigo is an illusion of rotation that is caused by the asymmetry of neurological function of the right and left vestibular nuclei. The aim of this study was to compare the efficacy and side effects of oral betahistine with injectable promethazine in treatment of acute peripheral vertigo.Methods: In this double-blind clinical trial study, the patients with acute peripheral vertigo were assigned in the two groups: receiving promethazine intramuscularly at a dose of 25 mg (group A) and receiving 8 mg betahistine tablets (group B) and the severity of their vertigo was evaluated on the visual analog scale (VAS) scoring system. In addition, adverse events in both groups of patients were compared and evaluated.Results: A total of 162 patients (82 subjects in group A) participated in this study. The mean age, gender distribution, intensity and symptoms of vertigo were similar in both groups before the intervention. At 2 and 3 h after the intervention, the score of VAS in patients taking betahistine was significantly higher than promethazine. In addition, the clinical symptoms after taking betahistine were significantly less. Side effects seen in patients taking the promethazine include mainly drowsiness. After taking betahistine, the most common complication was abdominal problems (nausea and vomiting).Conclusion: The results of this study show that betahistine is a safe and effective drug in controlling patients with acute vertigo and its impact is more than promethazine.J Clin Med Res. 2017;9(12):994-997doi: https://doi.org/10.14740/jocmr3093w
机译：背景：眩晕是旋转的错觉，其是由右前庭核的神经功能的不对称性引起的。本研究的目的是比较口腔甲板的疗效和副作用在治疗急性周围眩晕中的注射丙嗪。方法：在这种双盲临床试验研究中，急性周围眩晕患者分配在两组中：在25mg（A组）的剂量下接受过嘌呤氨基吡啶，并接受8mgβ-纤维素片剂（B组），并在视觉模拟量表（VAS）评分系统上评估其眩晕的严重程度。此外，对两组患者的不良事件进行了比较和评估。结果：共有162名患者（A组的82名受试者）参与了这项研究。在干预之前，两组在眩晕的平均年龄，性别分布，强度和症状在两组中都相似。在干预后2和3小时，服用甲板的患者的VAS的得分明显高于丙嗪。此外，服用甲板发球菌后的临床症状显着较低。服用丙嗪的患者副作用主要包括嗜睡。服用胸腺后，最常见的并发症是腹部问题（恶心和呕吐）。结论：本研究的结果表明，贝列汀是控制急性眩晕患者的安全有效的药物，其影响远远超过Promethazine.J Clin Med res。 2017; 9（12）：994-997DOI：https://doi.org/10.14740/jocmr3093w

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