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Role of MMP-1, MMP-8 and MMP-9 gene polymorphisms in preterm birth

机译：MMP-1，MMP-8和MMP-9基因多态性在早产中的作用

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Novel approaches to preterm births are underway building upon our prior discoveries and probing into unknown discovery pathways. The recent findings showed a high affinity of MMP-9 in serum and its polymorphisms for preterm birth. This study, which is a hospital-based casea??control study, aims to investigate the association of MMP-1, MMP-8 and MMP-9 polymorphisms, and levels of MMP-9 in preterm birth. Increased level of MMP-9 was reported in cases as compared to control. The significant association of MMP-9 (-1562) CT (P = 0.001; OR = 1.44(CI = 0.97a??2.14)) and TTgenotype (P = 0.05;OR = 2.6 (CI = 1.46a??4.69)) were reported in preterm birth. Our findings suggest that the MMP-9 plays an important role in contributing preterm labour and this can be used as a diagnostic tool during pregnancy.
机译：新的早产患者在我们之前的发现和探测到未知的发现途径时正在建立。最近的发现显示了MMP-9在血清中的高亲和力及其用于早产的多态性。该研究是一种基于医院的Casea ??对照研究，旨在研究MMP-1，MMP-8和MMP-9多态性的关联，以及早产中的MMP-9水平。与对照相比，在病例中报告了MMP-9水平。 MMP-9（-1562）CT的显着关联（P = 0.001;或= 1.44（CI = 0.97A→2.14））和Ttgenotype（P = 0.05;或= 2.6（CI = 1.46A？4.69））在早产报告。我们的研究结果表明，MMP-9在促进早产劳动中起重要作用，这可以在怀孕期间用作诊断工具。

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