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首页> 外文期刊>Journal of International Medical Research >Analysis of factors associated with development of Bacille Calmette–Guérin inoculation site change in patients with Kawasaki disease
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Analysis of factors associated with development of Bacille Calmette–Guérin inoculation site change in patients with Kawasaki disease

机译：川崎病患者Bacille Calmette-Guérin接种位点变化的因素分析

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Objective The present study was performed to identify factors associated with a Bacille Calmette–Guérin (BCG) inoculation site change in patients with Kawasaki disease (KD). Methods Among patients who had received BCG vaccination and treatment for KD at our hospital from 2005 through 2016, 177 patients born in 2005 through 2016 were enrolled. The patients were divided into those with (n?=?83, change group) and without (n?=?94, no-change group) a BCG site change, and the patient demographics, clinical severity, blood examination results, and echocardiographic findings were compared between the two groups. Results The change group was younger at onset and had a shorter interval from vaccination to onset. A BCG site change was observed in patients who developed the onset of KD symptoms from 31 to 806 days after BCG vaccination. Multivariate analysis showed that the interval from vaccination was closely and positively associated with the BCG site change (hazard ratio?=?0.995, 95% confidence interval?=?0.993–0.997). Conclusion A BCG site change in patients with KD is most closely associated with the interval from BCG vaccination to onset.
机译：目的是进行本研究以识别与川崎病患者（KD）患者的Bacille Calmette-guérin（BCG）接种位点相关的因素。 2005年至2016年从2005年至2016年接受了BCG疫苗接种和治疗KD患者的患者的方法，已于2005年至2016年出生于2016年至2016年至2016年。将患者分成那些（n？= 83，变化组）和没有（n？= 94，无变化组）的BCG现场变化，患者人口统计，临床严重程度，血液检查结果和超声心动图在两组之间比较了结果。结果变化组在发病时更年轻，并且从疫苗接种开始时较短。在BCG疫苗接种后31至806天开发KD症状的患者中，观察到BCG位点变化。多变量分析表明，接种疫苗接种的间隔与BCG部位变化（危险比？= 0.995,95％置信区间？=？0.993-0.997）密切且呈正相关。结论KD患者的BCG位点变化与来自BCG疫苗接种的间隔最密切相关。

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