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首页> 外文期刊>Journal of King Saud University >Effect of propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials
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Effect of propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials

机译：蜂胶补充对C反应蛋白水平和其他炎症因素的影响：随机对照试验的系统审查和荟萃分析

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Propolis is a resin-like substance collected by honeybees from certain plants that have been shown to positive effect on inflammatory factors. Therefore, the aim of this study was to systematically review and meta-analyse the effects of Propolis supplementation on CRP, TNF-a, IL-1, and IL-6 in Randomized Controlled Trials (RCTs). A comprehensive systematic search of articles was conducted in PubMed/MEDLINE, Web of sciences, and Scopus to identify the potential titles up to August 2019. PRISMA guidelines were performed for this study. Inclusion was 1-study design was parallel or cross over randomized controlled trial (RCT), 2- consumption of Propolis as intervention, 3- reported sufficient information about inflammatory factors, CRP, IL1, IL6, TNF-a. Six studies were identified by comprehensive search. This meta-analysis study found a significant reduction in IL-6, CRP, and TNF-α following Propolis consumption (Weighted mean differences (WMD): ?17.96?pg/ml, 95% CI: ?35.53, ?0.38, I2?=?98%), (WMD: ?1.16?pg/ml, 95% CI: ?2.28, ?0.03, I2?=?97%), and (WMD: ?34.08?pg/ml, 95% CI: ?60.25, ?7.91, I2?=?97%), respectively. Propolis did not showed any significant effect on IL-1 (WMD: ?17.36?pg/ml, 95% CI: ?37.60, 2.87, I2?=?97%). In conclusion, the results demonstrated that CRP, TNF-a and IL-6 were significantly reduced following propolis supplementation.
机译：蜂胶是一种由来自某些植物的蜂窝收集的树脂状物质，该植物已被证明对炎症因子的积极作用。因此，本研究的目的是系统地审查和荟萃分析随机对照试验（RCT）中CRP，TNF-A，IL-1和IL-6对CRP，TNF-A，IL-1和IL-6的影响。全面的系统搜索文章，在PubMed / Medline，Sciences，和Scopus中进行，以确定潜在的职称，达到2019年8月。普明目准则进行了本研究。包容性是1研究设计并平行或交叉于随机对照试验（RCT），2-消耗蜂胶作为干预，3-报告有关炎症因子，CRP，IL1，IL6，TNF-A的足够信息。通过全面搜索确定六项研究。该荟萃分析研究发现，蜂胶消费后IL-6，CRP和TNF-α显着降低（加权平均差异（WMD）：17.96？PG / mL，95％CI：？35.53，？0.38，I2？ =？98％），（WMD：？1.16？Pg / ml，95％CI：？2.28，？0.03，I2？= 97％），（WMD：？34.08？PG / ml，95％CI：？ 60.25，？7.91，I2？=？97％）。蜂胶对IL-1没有显示出任何显着影响（WMD：17.36？pg / ml，95％CI：？37.60,2.87，I2？=？97％）。总之，结果表明，在蜂胶补充剂后，CRP，TNF-A和IL-6显着降低。

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