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首页> 外文期刊>Journal of Neural Transplantation and Plasticity: Neural Plasticity >Memory and Cognition-Related Neuroplasticity Enhancement by Transcranial Direct Current Stimulation in Rodents: A Systematic Review
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Memory and Cognition-Related Neuroplasticity Enhancement by Transcranial Direct Current Stimulation in Rodents: A Systematic Review

机译：啮齿动物中经颅直流刺激的记忆和认知相关的神经塑性增强：系统审查

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Brain stimulation techniques, including transcranial direct current stimulation (tDCS), were identified as promising therapeutic tools to modulate synaptic plasticity abnormalities and minimize memory and learning deficits in many neuropsychiatric diseases. Here, we revised the effect of tDCS on the modulation of neuroplasticity and cognition in several animal disease models of brain diseases affecting plasticity and cognition. Studies included in this review were searched following the terms (“transcranial direct current stimulation”) AND (mice OR mouse OR animal) and according to the PRISMA statement requirements. Overall, the studies collected suggest that tDCS was able to modulate brain plasticity due to synaptic modifications within the stimulated area. Changes in plasticity-related mechanisms were achieved through induction of long-term potentiation (LTP) and upregulation of neuroplasticity-related proteins, such as c-fos, brain-derived neurotrophic factor (BDNF), or N-methyl-D-aspartate receptors (NMDARs). Taken into account all revised studies, tDCS is a safe, easy, and noninvasive brain stimulation technique, therapeutically reliable, and with promising potential to promote cognitive enhancement and neuroplasticity. Since the use of tDCS has increased as a novel therapeutic approach in humans, animal studies are important to better understand its mechanisms as well as to help improve the stimulation protocols and their potential role in different neuropathologies.
机译：脑刺激技术（包括经颅直流刺激（TDC）都被确定为有前途的治疗工具，以调节突触可塑性异常，并最大限度地减少许多神经精神疾病中的记忆和学习缺陷。在这里，我们修改了TDC对影响可塑性和认知的脑病的几种动物疾病模型的神经塑性和认知调节的影响。在术语（“经颅直流刺激”）和（小鼠或鼠标或动物）之后搜查了本综述中的研究，并根据PRISMA陈述要求。总体而言，收集的研究表明，由于刺激区域内的突触修饰，TDC能够调节脑可塑性。通过诱导长期增强（LTP）和神经塑性相关蛋白质的上调，例如C-FOS，脑衍生的神经营养因子（BDNF）或N-甲基-D-天冬氨酸受体来实现可塑性相关机制的变化。 （NMDARS）。考虑到所有修订的研究，TDC是一种安全，简单，无创脑刺激技术，治疗上可靠，并且有希望促进认知增强和神经塑性的潜力。由于TDC的使用随着人类的新疗法方法而增加，因此动物研究对于更好地了解其机制以及有助于改善刺激方案及其在不同神经病理学中的潜在作用。

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