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Stress Management in Women with Hashimoto’s thyroiditis: A Randomized Controlled Trial

机译：患有Hashimoto甲状腺炎的女性的压力管理：随机对照试验

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Aim: Stress has been implicated in the pathogenesis of Hashimoto's thyroiditis (HT), nevertheless evidence is scarce regarding the effect of stress management on individuals suffering from HT. The purpose of this study was to evaluate the impact of an 8-week stress management intervention on the anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies as well as thyroid-stimulating hormone (TSH) levels of women with HT. Secondary endpoints included the effect on the patients’ lifestyle, body mass index (BMI), depression, anxiety and stress. Methods: This was a two-arm parallel group (stress management intervention vs. standard care groups) randomized controlled study. Adult women with Hashimoto's thyroiditis, completed questionnaires on stress, anxiety, depression and lifestyle, at the beginning of the programme and 8 weeks later. Laboratory thyroid function tests (anti-TPO, anti-TG antibodies and TSH) were also measured at baseline and at the end of the study. Results: A total of 60 women with HT, aged 25-76 years, participated in the study (30 patients in each group). After eight weeks, patients in the intervention group demonstrated statistically significant beneficial decrements in the rate change of anti-TG titers and the levels of stress, depression and anxiety as well as better lifestyle scores, compared to the control group.
机译：目的：压力涉及Hashimoto的甲状腺炎（HT）的发病机制，尽管有关于患有HT的个体的压力管理效果缺乏证据。本研究的目的是评估8周应力管理干预对抗甲状腺过氧化物酶（抗TPO）和抗甲状腺球蛋白（抗TG）抗体以及甲状腺刺激激素（TSH）水平的影响妇女与ht。次要终点包括对患者的生活方式，体重指数（BMI），抑郁，焦虑和压力的影响。方法：这是一个双臂平行组（应力管理干预与标准护理组）随机对照研究。哈希莫氏菌炎的成年女性，在节目开始时完成了压力，焦虑，抑郁和生活方式的调查问卷和8周后。在基线和研究结束时，还测量了实验室甲状腺功能测试（抗TPO，抗TG抗体和TSH）。结果：共有60名HT，25-76岁的女性参加了该研究（每组30名患者）。八周后，干预组的患者表现出抗对照组的抗TG滴度的速率变化和压力，抑郁和焦虑水平的统计上显着的有益递减，以及与对照组相比更好的生活方式评分。

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