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首页> 外文期刊>Journal of the International Society of Sports Nutrition >Acute supplementation with an amino acid mixture suppressed the exercise-induced cortisol response in recreationally active healthy volunteers: a randomized, double-blinded, placebo-controlled crossover study
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Acute supplementation with an amino acid mixture suppressed the exercise-induced cortisol response in recreationally active healthy volunteers: a randomized, double-blinded, placebo-controlled crossover study

机译：氨基酸混合物的急性补充抑制了运动诱导的娱乐健康志愿者的皮质醇反应：随机，双盲，安慰剂控制的交叉研究

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BACKGROUND:Few studies have demonstrated the suppressive effects of amino acids (AAs) on the level of cortisol during exercise in humans. We hypothesized that an AA mixture containing arginine, which promotes lipid metabolism, valine, which effectively decreases the level of glucocorticoid, and serine, a substrate in the production of phosphatidylserine that is reported to blunt increases in cortisol, would suppress the exercise-induced cortisol response by combining the positive effects of the AAs synergistically.METHODS:A randomized, double-blinded, placebo-controlled crossover trial was conducted. Twenty healthy recreationally active males ingested either an AA mixture containing 1.8?g of arginine, 1.1?g of valine, and 0.1?g of serine or a placebo. Thirty minutes after ingestion, subjects performed an exercise trial on a cycle ergometer for 80?min at 50% maximal oxygen consumption. Plasma cortisol and other blood parameters immediately before and after the exercise were evaluated.RESULTS:Plasma cortisol concentrations after exercise were significantly higher than those before exercise in the placebo condition (9.51?±?0.85 vs 14.39?±?2.15, p??0.05), while there was no significant difference in the AA condition (9.71?±?0.93 vs 9.99?±?1.23, p?=?0.846). In addition, the increase in plasma cortisol before and after exercise was significantly lower in the AA condition than in the placebo condition (0.28 [-?2.75, 3.31] vs 4.87 [0.89, 8.86], p??0.05). For the level of adrenocorticotropin, there was a significant difference between before and after exercise only in the placebo condition (24.21?±?2.91 vs 53.17?±?6.97, p??0.01) but not in the AA condition (27.33?±?3.60 vs 46.92?±?10.41, p?=?0.057). Blood glucose, plasma lactate, plasma ammonia, serum creatine phosphokinase, serum total ketone body, and serum free fatty acid were also significantly changed by the exercise load in both conditions, but no significant differences were observed between the two conditions.CONCLUSIONS:The present study demonstrated that the AA mixture suppressed the cortisol response during exercise without affecting exercise-related biological parameters such as glucose or lipid metabolism.TRIAL REGISTRATION:UMIN Clinical Trials Registry, UMIN000023587 . Registered 19 August 2016.
机译：背景：很少有研究已经证明氨基酸（AAS）在人类运动期间对皮质醇水平的抑制作用。我们假设含有精氨酸的AA混合物，其促进脂质代谢的缬氨酸，有效地降低葡萄糖素水平，丝氨酸的磷酸丝丝氨酸的水合物，据报道的磷酸丝丝氨酸在皮质醇中增加，将抑制运动诱导的皮质醇通过组合AAS协同的正效应来回应。方法：进行随机，双盲，安慰剂控制的交叉试验。 20次健康的娱乐活性雄性摄入含有1.8·g精氨酸的AA混合物，1.1〜缬氨酸，0.1·g丝氨酸或安慰剂。摄入30分钟后，受试者在循环测力计上进行运动试验80？分钟以最大氧气消耗50％。血浆皮质醇和锻炼前后的其他血液参数评估。结果：运动后的血浆皮质醇浓度明显高于安慰剂条件（9.51？±0.85 Vs 14.39？±2.15，P？<？ 0.05），虽然AA条件下没有显着差异（9.71？±0.93 Vs 9.99？±1.23，p？= 0.846）。此外，在AA条件下运动之前和锻炼之前和之后的血浆皮质醇的增加显着降低（0.28 [ - β.-β.75,3.31] Vs 4.87 [0.89,8.86]，P？<0.05）。对于肾上腺皮质激素的水平，仅在安慰剂条件下运动之前和之后存在显着差异（24.21？±2.91 Vs 53.17？±6.97，P？<？0.01），但不在AA条件下（27.33？± ？3.60 vs 46.92？±10.41，p？= 0.057）。血糖，血浆乳酸，血浆氨，血清肌酸磷酸氨基酶，血清全酮体和血清自由脂肪酸也受到两种条件的运动负荷显着改变，但在两个条件下没有观察到显着差异。结论：目前：现在研究证明AA混合物在运动期间抑制了皮质醇反应，而不会影响与葡萄糖或脂质代谢等运动相关的生物学参数.Tirial注册：Umin临床试验登记处，UMIN000023587。注册2016年8月19日。

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