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首页> 外文期刊>Journal of Zhejiang University. Science, B >Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment*
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Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment*

机译：无针注射胰岛素粉末：输送效率和皮肤刺激评估*

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摘要

insulin is widely used in treating diabetes, but still needs to be administered by needle injection. This study investigated a new needle-free approach for insulin delivery. A portable powder needleless injection (PNI) device with an automatic mechanical unit was designed. Its efficiency in delivering insulin was evaluated in alloxan-induced diabetic rabbits. The skin irritation caused by the device was investigated and the results were analyzed in relation to aerodynamic parameters. Inorganic salt-carried insulin powders had hypoglycemic effects, while raw insulin powders were not effective when delivered by PNI, indicating that salt carriers play an important role in the delivery of insulin via PNI. The relative delivery efficiency of phosphate-carried insulin powder using the PNI device was 72.25%. A safety assessment test showed that three key factors (gas pressure, cylinder volume, and nozzle distance) were related to the amount of skin irritation caused by the PNI device. Optimized injection conditions caused minimal skin lesions and are safe to use in practice. The results suggest that PNI has promising prospects as a novel technology for delivering insulin and other biological drugs.
机译：胰岛素广泛用于治疗糖尿病，但仍然需要通过针注射给药。本研究调查了一种用于胰岛素递送的新无针方法。设计了一种带有自动机械单元的便携式粉末注射（PNI）装置。其在含有胰岛素诱导的糖尿病兔中评价其胰岛素的效率。研究了该装置引起的皮肤刺激，并与空气动力学参数分析结果。无机盐携带的胰岛素粉末具有低血糖作用，而原料胰岛素粉末在通过PNI送出时无效，表明盐载体在通过PNI递送胰岛素中发挥着重要作用。使用PNI器件的磷酸盐载胰岛素粉的相对输送效率为72.25％。安全评估测试显示，三个关键因素（气体压力，气缸体积和喷嘴距离）与PNI器件引起的皮肤刺激量有关。优化的注射条件引起了最小的皮肤病变，在实践中使用安全。结果表明，PNI具有前景作为一种促进胰岛素和其他生物药物的新技术。

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