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首页> 外文期刊>Journal of Thoracic Disease >Adverse events after pleurodesis in patients with malignant pleural effusion
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Adverse events after pleurodesis in patients with malignant pleural effusion

机译：恶性胸腔积液患者血尿病患者后的不良事件

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Background: Malignant pleural effusion (MPE) is an important sign of advanced disease in metastatic cancer. Pleurodesis is one option to treat recurrent MPE. The Inflammatory response after pleurodesis may lead to important adverse events (AE) in a set of very ill patients. Methods: Retrospective analysis of patients submitted to pleurodesis (2009–2013). Clinical and laboratory data were collected. We compare the values in the day of pleurodesis, 2nd, 5th and 10th days after. Results: One hundred fourteen patients were undergone to pleurodesis with silver nitrate (46%), iodine (52%) and talc (2%). Female was the most frequent (86%) and the breast cancer was the most common primary site. The most frequent adverse event was low hemoglobin account (37), followed by pain (31). 68% of patients presented AEs and 28% had at least one AE with grade 3 or higher. The most altered was CRP that peaked in the 5th day after pleurodesis. Changes in CRP curve were less severe with the use of iodine when compared with the other two agents. Conclusions: Pleurodesis leads to important systemic inflammatory response detected by different serum markers. The occurrence of adverse events in this set of patients was great number of events with being marked as grade 3 or higher.
机译：背景：恶性胸腔积液（MPE）是转移性癌症晚期疾病的重要标志。胸膜瘤性是治疗复发MPE的一种选择。胸膜瘤病后的炎症反应可能导致一套生病的患者中的重要不良事件（AE）。方法：对提交给胸膜瘤的患者的回顾性分析（2009-2013）。收集了临床和实验室数据。我们比较胸膜炎，第5天和第10天的日期的价值观。结果：用硝酸银（46％），碘（52％）和滑石（2％）经过一百十四名患者对血管瘤病毒。女性是最常见的（86％），乳腺癌是最常见的主要部位。最常见的不良事件是低血红蛋白账户（37），其次是疼痛（31）。 68％的患者呈现AES和28％的患者至少有一个AE，3级或更高等级。最改变的是CRP在胸膜炎患者第5天达到峰值。与其他两个药剂相比，CRP曲线的变化较小，使用碘对碘进行。结论：胸膜瘤术导致不同血清标志物检测的重要全身炎症反应。这组患者的不良事件发生的发生是众多事件，标记为3级或更高。

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