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首页> 外文期刊>Cureus. >Human Herpesvirus-8 Negative Multicentric Castleman Disease in a Patient with Human Immunodeficiency Virus Treated with Highly Active Antiretroviral Therapy and Chemotherapy
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Human Herpesvirus-8 Negative Multicentric Castleman Disease in a Patient with Human Immunodeficiency Virus Treated with Highly Active Antiretroviral Therapy and Chemotherapy

机译：人类疱疹病毒-8阴性多中心Castleman病，患者用高活性抗逆转录病毒治疗和化疗治疗人体免疫缺陷病毒

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摘要

Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder with a high mortality rate in undiagnosed patients.?Traditionally, human immunodeficiency virus (HIV) positive MCD occurs due to infection with human herpes virus-8 (HHV), which is thought to play a role in the pathogenesis of MCD.?We present the case of a 49-year-old woman who was referred to our oncology clinic for generalized lymphadenopathy in a waxing and waning pattern for the last four years.?She was found to be HIV positive.?Here we report a rare case of HIV-positive, HHV-negative MCD that responded to prompt treatment with highly active antiretroviral therapy (HAART) followed by chemotherapy as evidenced by improved CD4+ T cell numbers and reduction in lymphadenopathy.?The findings in this HHV?seronegative patient may indicate an alteration in the virulence and tropism between HHV?and HIV, and further demonstrate the need for continued investigation into the pathogenesis of Castleman disease.
机译：多中心卡斯勒病（MCD）是一种罕见的淋巴抑制性疾病，在未确诊的患者中具有高死亡率。当被认为可以发挥的人疱疹病毒-8（HHV）感染，发生了人类免疫缺陷病毒（HIV）阳性MCD。在MCD的发病机制中的作用呈现了一个49岁女性的案例，该女性在过去的四年中，在旺盛和失败的模式中提到了广义淋巴结病的肿瘤诊所。？发现是艾滋病毒阳性。我们报告罕见的艾滋病毒阳性HHV阴性MCD的病例，其响应于高活性抗逆转录病毒治疗（HAART），然后通过改善的CD4 + T细胞数证明和淋巴结病的减少所证明的化学疗法。发现在这种HHV中？血清基因患者可能表明HHV之间的毒力和热衷于毒力和艾滋病病毒，并进一步证明需要继续调查Castleman病的发病机制。

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