Triarylethylene-indolin-2,3-dione molecular conjugates: design, synthesis, docking studies and anti-proliferation evaluation

Sumit Kumar; Gabriella Palma; Shanen Perumal; Mandeep Kaur; Ashona Singh-Pillay; Raghu Raj; Parvesh Singh; Vipan Kumar

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Triarylethylene-indolin-2,3-dione molecular conjugates: design, synthesis, docking studies and anti-proliferation evaluation

机译：三亚甲基 - 吲哚啉-2,3-二酮分子缀合物：设计，合成，对接研究和抗扩散评估

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A series of 1 H -1,2,3-triazole-linked ospemifene-isatin and O -methylated ospemifene–isatin conjugates were synthesized and assayed for their anti-proliferative activities against estrogen-responsive as well as estrogen-non-responsive cells. The non-cytotoxic conjugate 14e , with an optimal combination of bromo substituents at the C-5/C-7 positions of isatin, proved to be a promising hit with an IC _(50) value of 31.62 μM against MCF-7 and 19.23 μM against MDA-MB-231. The observed anti-proliferative activities of active conjugates were further corroborated via docking studies carried out on estrogen receptor subtypes α and β.

机译：合成了一系列1 H -1,2,3-三唑型连接的OSPemifene-Isatin和O-甲基化奥己二烯 - Isatin缀合物，并测定它们对雌激素响应性以及雌激素非响应细胞的抗增殖活动。非细胞毒性缀合物14E，在Isatin的C-5 / C-7位置处具有最佳的溴代取代基组合，证明是对MCF-7和19.23的IC _（50）值31.62μm的有希望的击中对MDA-MB-231μm。通过对雌激素受体亚型α和β进行的对接研究进一步证实了活性缀合物的观察到的活性缀合物的活性。

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《RSC Advances》 |2019年第72期|共6页
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Sumit Kumar; Gabriella Palma; Shanen Perumal; Mandeep Kaur; Ashona Singh-Pillay; Raghu Raj; Parvesh Singh; Vipan Kumar;
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机译：三亚甲基 - 吲哚啉-2,3-二酮分子缀合物：设计，合成，对接研究和抗扩散评估
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Triarylethylene-indolin-2,3-dione molecular conjugates: design, synthesis, docking studies and anti-proliferation evaluation

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