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首页> 外文期刊>RSC Advances >In vitro anticancer activity of parent and nano-encapsulated samarium(iii) complex towards antimicrobial activity studies and FS-DNA/BSA binding affinity
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In vitro anticancer activity of parent and nano-encapsulated samarium(iii) complex towards antimicrobial activity studies and FS-DNA/BSA binding affinity

机译：对父母和纳米植物（III）复合物的体外抗癌活性朝向抗菌活性研究和FS-DNA / BSA结合亲和力

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摘要

Based on the potential anticancer properties of lanthanide complexes, the anticancer activity of the Sm( III ) complex containing a 2,2′-bipyridine ligand (bpy) and its interaction with FS-DNA (Fish-Salmon DNA) and BSA (Bovine Serum Albumin) were examined experimentally and by molecular docking in this paper. Absorption and fluorescence spectroscopic methods were used to define the thermodynamic parameters, binding constant ( K _(b) ), and the probable binding mechanism. It was concluded that the Sm complex interacts with FS-DNA through a minor groove with a K _(b) of 10 ~(5) M ~(?1) . Also, the K _(b) for the BSA binding at 298 K was found to be 5.89 × 10 ~(5) M ~(?1) , showing relatively a high tendency of the Sm complex to DNA and BSA. Besides, the Sm complex was docked to BSA and DNA by the autodock program. The results of the docking calculations were in good agreement with the experimental examinations. Additionally, the antifungal and antibacterial properties of this complex were investigated. The anticancer tests on the effect of the Sm complex, starch nano-encapsulation, and lipid nano-encapsulation in MCF-7 and A-549 cell lines were performed by the MTT method. It can be observed that the Sm complex and its nanocarriers presented a selective inhibitory effect on various cancer cell growths.
机译：基于镧系元素复合物的潜在抗癌性质，含有2,2'-硼吡啶配体（BPY）的SM（III）络合物的抗癌活性及其与FS-DNA（鱼 - 鲑鱼DNA）和BSA的相互作用（牛血清通过实验检查白蛋白并通过本文进行分子对接。使用吸收和荧光光谱法用于定义热力学参数，结合常数（K _（B））和可能的结合机制。得出结论是，SM复合物通过k _（b）为10〜（5）m〜（α1）的浅槽与Fs-DNA相互作用。此外，发现BSA结合的K _（b）在298k下被发现为5.89×10〜（5）m〜（α1），显示SM复合物与DNA和BSA的高趋势。此外，SM复合物由Autodock程序停靠在BSA和DNA上。对接计算的结果与实验检查吻合良好。另外，研究了该络合物的抗真菌和抗菌性质。通过MTT方法进行MCF-7和A-549细胞系中SM复合物，淀粉纳米封装和脂质纳米包封效应的抗癌试验。可以观察到SM复合物及其纳米载体对各种癌细胞生长呈现了一种选择性抑制作用。

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