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首页> 外文期刊>RSC Advances >Parent and nano-encapsulated ytterbium(iii) complex toward binding with biological macromolecules,in vitrocytotoxicity, cleavage and antimicrobial activity studies
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Parent and nano-encapsulated ytterbium(iii) complex toward binding with biological macromolecules,in vitrocytotoxicity, cleavage and antimicrobial activity studies

机译：父母和纳米封装的镱（III）复合物与生物大分子结合，在挥橘毒性，切割和抗微生物活性研究中

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摘要

To determine the chemotherapeutic and pharmacokinetic aspects of an ytterbium complex containing 2,9-dimethyl-1,10-phenanthroline (Me(2)Phen),in vitrobinding studies were carried out with FS-DNA/BSA by employing multiple biophysical methods and a molecular modeling study. There are different techniques including absorption spectroscopy, fluorescence spectroscopy, circular dichroism studies, viscosity experiments (only in the case of DNA), and competitive experiments used to determine the interaction mode between DNA/BSA and the ytterbium-complex. The results showed that the Yb-complex exhibited a high propensity for the interaction of BSA and DNAviahydrophobic interactions and van der Waals forces. Further, a competitive examination and docking study showed that the interaction site of the ytterbium complex on BSA is site III. The results of docking calculations for DNA/BSA were in good agreement with experimental findings. The complex displays efficient DNA cleavage in the presence of hydrogen peroxide. Moreover, antimicrobial studies of different bacteria and fungi indicated its promising antibacterial activity.In vitrocytotoxicity studies of the Yb-complex, starch nano-encapsulated, and lipid nano-encapsulated were carried out in MCF-7 and A-549 cell lines, which revealed significantly good activity. The results of anticancer activity studies showed that the cytotoxic activity of the Yb-complex was increased when encapsulated with nanocarriers. Based on biological applications of the Yb-complex, it can be concluded that this complex and its nanocarriers can act as novel anticancer and antimicrobial candidates.
机译：为了确定含有2,9-二甲基-1,10-膦壶（ME（2）份）的YTTerbium络合物的化学治疗和药代动力学方面，通过采用多种生物物理方法和a，用FS-DNA / BSA进行vitro脱核化学研究。分子建模研究。存在不同的技术，包括吸收光谱，荧光光谱，圆形二色性研究，粘度实验（仅在DNA的情况下），以及用于确定DNA / BSA和YTTERBIUM-复合物之间的相互作用模式的竞争实验。结果表明，Yb-综合体表现出BSA和二伐酰基杂交相互作用和范德瓦尔斯力的相互作用的高度倾向。此外，竞争性检查和对接研究表明，BSA上的YTterbium复合物的相互作用位点是地点III。与实验发现，DNA / BSA的对接计算结果良好。该复合物在过氧化氢的存在下显示有效的DNA裂解。此外，不同细菌和真菌的抗菌研究表明了其有前途的抗菌活性。在MCF-7和A-549细胞系中进行YB-复合物，淀粉纳米包封和脂质纳米封装的挥霍细胞毒性研究。显着良好的活动。抗癌活性研究结果表明，当用纳米载体包封时，Yb-复合物的细胞毒性活性增加。基于YB-复合物的生物学应用，可以得出结论，这种复合物及其纳米载体可以作为新的抗癌和抗微生物候选者。

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  • 来源
    《RSC Advances》 |2020年第39期|共14页
  • 作者

    Aramesh-Boroujeni Zahra; Jahani Shohreh; Khorasani-Motlagh Mozhgan; Kerman Kagan; Noroozifar Meissam;

  • 作者单位

    Isfahan Univ Med Sci AlZahra Hosp Dept Clin Lab Esfahan Iran;

    Bam Univ Med Sci Nano Bioeletrochem Res Ctr Bam Iran;

    Univ Sistan &

    Baluchestan Dept Chem Zahedan 98135674 Iran;

    Univ Toronto Scarborough Dept Phys &

    Environm Sci 1265 Mil Trail Toronto ON M1C 1A4 Canada;

    Univ Toronto Scarborough Dept Phys &

    Environm Sci 1265 Mil Trail Toronto ON M1C 1A4 Canada;

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  • 正文语种 eng
  • 中图分类 化学;
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