Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F

Siqiang Li; Hong Wang; Guoxia Jin; Zonggang Chen; Guofeng Gu

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Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F

机译：从链球菌血管型23F探索胸腺嘧啶吡啶酸乙烯基酸CPS23FL的较大核苷酸三磷酸盐和糖-1-磷酸盐特异性

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Glucose-1-phosphate thymidylyltransferase (Cps23FL) from Streptococcus pneumonia serotype 23F is the initial enzyme that catalyses the thymidylyl transfer reaction in prokaryotic deoxythymidine diphosphate- L -rhamnose (dTDP-Rha) biosynthetic pathway. In this study, the broad substrate specificity of Cps23FL towards six glucose-1-phosphates and nine nucleoside triphosphates as substrates was systematically explored, eventually providing access to nineteen sugar nucleotide analogs.

机译：来自链球菌血管型血管型23F的葡萄糖-1-磷酸盐脂肪酰基转移酶（CPS23FL）是催化初始酶，其催化原核脱氧萘胺二磷酸二磷酸-L -Rhamnose（DTDP-RHA）生物合成途径中的胸腺嘧啶转移反应。在该研究中，系统探讨了CPS23FL朝向六个葡萄糖-1-磷酸醚和九个核苷三磷酸的宽底物特异性，最终提供对等十九糖核苷酸类似物的途径。

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《RSC Advances》 |2020年第50期|共5页
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Siqiang Li; Hong Wang; Guoxia Jin; Zonggang Chen; Guofeng Gu;
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1. Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL fromStreptococcus pneumoniaserotype 23F [J] . Li Siqiang, Wang Hong, Jin Guoxia, RSC Advances . 2020,第50期

机译：探索胸苷三磷酸的大核苷酸三磷酸和糖-1-磷酸盐特异性，CPS23FLFOLFSTREPTOCCCCUSIAserotype 23F
2. Combinatorial Library Cloning of Human Antibodies to Streptococcus pneumoniae Capsular Polysaccharides: Variable Region Primary Structures and Evidence for Somatic Mutation of Fab Fragments Specific for Capsular Serotypes 6B, 14, and 23F [J] . Alexander H. Lucas, Karen D. Moulton, Vanessa R. Tang, Infection and immunity . 2001,第2期

机译：肺炎链球菌荚膜多糖人类抗体的组合文库克隆：可变区一级结构和特定于荚膜血清型6B，14和23F的Fab片段体细胞突变的证据。
3. Genetic and structural elucidation of capsular polysaccharides from Streptococcus pneumoniae serotype 23A and 23B, and comparison to serotype 23F [J] . Ravenscroft Neil, Omar Aneesa, Hlozek Jason, Carbohydrate research . 2017,第期

机译：来自链球菌血管型23a和23b的囊多糖的遗传和结构阐明，与血清型23f比较
4. COMPARISON OF CAPSULAR POLYSACCHARIDE CONFORMATIONS IN STREPTOCOCCUS AGALACTIAE SEROTYPE III AND STREPTOCOCCUS PNEUMONIAE SEROTYPE 14: IMPLICATIONS FOR IMMUNOGENICS. [C] . Michelle M. Kuttel, Neil Ravenscroft International Carbohydrate Symposium . 2018

机译：链球菌血清型III和链球菌血管型血管型血管型血管型血管型血管型14的比较14：免疫学的影响。
5. Characterization of the role that bacterial surface polysaccharide poly n-acetyl glucosamine plays in non-vaccine serotypes of Streptococcus pneumonia colonization and pathogenicity [D] . Jiang, Fanny 2015

机译：表征细菌表面多糖聚正乙酰氨基葡萄糖在非疫苗血清型肺炎链球菌定殖和致病性中的作用
6. Antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae isolated from patients with community-acquired pneumonia and molecular analysis of multidrug-resistant serotype 19F and 23F strains in Japan [O] . L. QIN, H. WATANABE, H. YOSHIMINE, 2006

机译：日本社区获得性肺炎患者肺炎链球菌的耐药性和血清型分布及多药耐药的19F和23F血清型的分子分析
7. Combinatorial Library Cloning of Human Antibodies to Streptococcus pneumoniae Capsular Polysaccharides: Variable Region Primary Structures and Evidence for Somatic Mutation of Fab Fragments Specific for Capsular Serotypes 6B, 14, and 23F [O] . Lucas, Alexander H., Moulton, Karen D., Tang, Vanessa R., 2001

机译：肺炎链球菌荚膜多糖人类抗体的组合文库克隆：可变区一级结构和特定于荚膜血清型6B，14和23F的Fab片段的体细胞突变的证据。

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Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F

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