A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug

Artur Kasprzak; Bart?omiej Dabrowski; Agnieszka Zuchowska

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A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug

机译：一种生物相容的聚（酰胺）（PAMAM）树枝状体Octa-取代α-环糊精朝向其盐酸二十甲素蛋白盐酸盐的控制释放

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Facile and efficient methods for the synthesis of the first poly(aminodamine) PAMAM G1.0 dendrimer octa-substituted with α-cyclodextrin and a novel ferrocenyl prodrug of doxorubicin hydrochloride are developed. This vector is non-toxic and can bind the designed ferrocenyl prodrug. It also shows a controlled drug release profile and high cytotoxicity against breast cancer cells (MCF-7), as elucidated by the in vitro biological studies performed with an innovative cell-on-a-chip microfluidic system.

机译：开发了适用于合成第一聚（氨基氨基胺）PAMAM G1.0 Dendrimer Octa-取代的具有α-环糊精和多柔枯辛素盐酸盐的新型二氧化钴素前药。该载体无毒，可以粘合设计的菲罗基苯基前药。它还显示了对乳腺癌细胞（MCF-7）的受控药物释放曲线和高细胞毒性，其通过具有创新的细胞对芯片微流体系统进行的体外生物学研究阐明。

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《RSC Advances》 |2020年第39期|共6页
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Artur Kasprzak; Bart?omiej Dabrowski; Agnieszka Zuchowska;
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1. A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with alpha-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug [J] . Kasprzak Artur, Dabrowski Barttomiej, Zuchowska Agnieszka RSC Advances . 2020,第39期

机译：一种生物相容的聚（酰胺）（PAMAM）Dendrimer Octa-取代α-环糊精从其二茂铁前药中的盐酸盐素的控制释放
2. Controlled molecular conformation and morphology in poly(amidoamine) (PAMAM) and poly(propyleneimine) (DAB) dendrimers [J] . Donnio B., Barbera J., Gimenez R., Macromolecules . 2002,第2期

机译：聚（酰胺基胺）（PAMAM）和聚（丙烯亚胺）（DAB）树状聚合物中受控的分子构象和形态
3. Intracellular Ca2+ release mediates cationic but not anionic poly(amidoamine) (PAMAM) dendrimer-induced tight junction modulation. [J] . Brittany R Avaritt, Peter W Swaan Pharmaceutical research . 2014,第9期

机译：细胞内Ca2 +释放介导阳离子聚丁二酰胺诱导的紧密连接调节，但不介导阴离子聚（酰胺基胺）（PAMAM）。
4. Transport of Poly (Amidoamine) (PAMAM) Dendrimers Across Caco-2 Cell Monolayers: Influenceof Size, Charge and Fluorescent Labeling [C] . K. M. Kitchens, P. W. Swaan, H. Ghandehari Annual meeting exposition of the Controlled Release Society . 2005

机译：跨Caco-2细胞单层的聚（酰胺基胺）（PAMAM）树状聚合物的运输：大小，电荷和荧光标记的影响。
5. Engineering tumor-targeted poly(amidoamine) (PAMAM) dendrimers for improved penetration and cellular delivery of short-interfering RNA (siRNA) through solid tumors [D] . Waite, Carolyn Leigh 2011

机译：工程化靶向肿瘤的聚（酰胺基胺）（PAMAM）树状大分子，以提高短干扰RNA（siRNA）通过实体瘤的渗透和细胞递送
6. Nitric Oxide-Releasing Amphiphilic Poly(amidoamine) (PAMAM) Dendrimers as Antibacterial Agents [O] . Yuan Lu, Danielle L. Slomberg, Anand Shah, -1

机译：释放一氧化氮的两亲性聚（酰胺基胺）（PAMAM）树状聚合物作为抗菌剂
7. A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug [O] . Artur Kasprzak, Bartłomiej Dabrowski, Agnieszka Zuchowska 2020

机译：一种生物相容的聚（酰胺）（PAMAM）树枝状体Octa-取代α-环糊精朝向其盐酸二十甲素蛋白盐酸盐的控制释放

A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug

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