A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with alpha-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug

Kasprzak Artur; Dabrowski Barttomiej; Zuchowska Agnieszka

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A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with alpha-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug

机译：一种生物相容的聚（酰胺）（PAMAM）Dendrimer Octa-取代α-环糊精从其二茂铁前药中的盐酸盐素的控制释放

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Facile and efficient methods for the synthesis of the first poly(aminodamine) PAMAM G1.0 dendrimer octa-substituted with alpha-cyclodextrin and a novel ferrocenyl prodrug of doxorubicin hydrochloride are developed. This vector is non-toxic and can bind the designed ferrocenyl prodrug. It also shows a controlled drug release profile and high cytotoxicity against breast cancer cells (MCF-7), as elucidated by thein vitrobiological studies performed with an innovative cell-on-a-chip microfluidic system.

机译：开发了适用于合成第一聚（氨基氨基胺）PAMAM G1.0 Dendimer Octa-取代的α-环糊精和盐酸多柔比星的新型二氧锰基前药的合成的高效方法。该载体无毒，可以粘合设计的菲罗基苯基前药。它还显示了对乳腺癌细胞（MCF-7）的受控药物释放曲线和高细胞毒性，如用创新的芯片 - 芯片微流体系统进行的素素研究所阐明的。

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《RSC Advances》 |2020年第39期|共6页
作者
Kasprzak Artur; Dabrowski Barttomiej; Zuchowska Agnieszka;
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Warsaw Univ Technol Fac Chem Noakowskiego Str 3 PL-00664 Warsaw Poland;

Warsaw Univ Technol Fac Chem Noakowskiego Str 3 PL-00664 Warsaw Poland;

Warsaw Univ Technol Fac Chem Noakowskiego Str 3 PL-00664 Warsaw Poland;

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正文语种 eng
中图分类化学;
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1. A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with alpha-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug [J] . Kasprzak Artur, Dabrowski Barttomiej, Zuchowska Agnieszka RSC Advances . 2020,第39期

机译：一种生物相容的聚（酰胺）（PAMAM）Dendrimer Octa-取代α-环糊精从其二茂铁前药中的盐酸盐素的控制释放
2. Controlled molecular conformation and morphology in poly(amidoamine) (PAMAM) and poly(propyleneimine) (DAB) dendrimers [J] . Donnio B., Barbera J., Gimenez R., Macromolecules . 2002,第2期

机译：聚（酰胺基胺）（PAMAM）和聚（丙烯亚胺）（DAB）树状聚合物中受控的分子构象和形态
3. Intracellular Ca2+ release mediates cationic but not anionic poly(amidoamine) (PAMAM) dendrimer-induced tight junction modulation. [J] . Brittany R Avaritt, Peter W Swaan Pharmaceutical research . 2014,第9期

机译：细胞内Ca2 +释放介导阳离子聚丁二酰胺诱导的紧密连接调节，但不介导阴离子聚（酰胺基胺）（PAMAM）。
4. Transport of Poly (Amidoamine) (PAMAM) Dendrimers Across Caco-2 Cell Monolayers: Influenceof Size, Charge and Fluorescent Labeling [C] . K. M. Kitchens, P. W. Swaan, H. Ghandehari Annual meeting exposition of the Controlled Release Society . 2005

机译：跨Caco-2细胞单层的聚（酰胺基胺）（PAMAM）树状聚合物的运输：大小，电荷和荧光标记的影响。
5. Engineering tumor-targeted poly(amidoamine) (PAMAM) dendrimers for improved penetration and cellular delivery of short-interfering RNA (siRNA) through solid tumors [D] . Waite, Carolyn Leigh 2011

机译：工程化靶向肿瘤的聚（酰胺基胺）（PAMAM）树状大分子，以提高短干扰RNA（siRNA）通过实体瘤的渗透和细胞递送
6. Nitric Oxide-Releasing Amphiphilic Poly(amidoamine) (PAMAM) Dendrimers as Antibacterial Agents [O] . Yuan Lu, Danielle L. Slomberg, Anand Shah, -1

机译：释放一氧化氮的两亲性聚（酰胺基胺）（PAMAM）树状聚合物作为抗菌剂
7. A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug [O] . Artur Kasprzak, Bartłomiej Dabrowski, Agnieszka Zuchowska 2020

机译：一种生物相容的聚（酰胺）（PAMAM）树枝状体Octa-取代α-环糊精朝向其盐酸二十甲素蛋白盐酸盐的控制释放

A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with alpha-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug

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