Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes

Elena B. Rakhimova; Victor Yu. Kirsanov; Elena V. Tretyakova; Leonard M. Khalilov; Askhat G. Ibragimov; Lilya U. Dzhemileva; Vladimir A. Dyakonov; Usein M. Dzhemilev

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Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes

机译：2,9-二取代的perydro 2,3a，7b，9,9,10a，14b-六氮氮向导异细胞的合成，结构和抗肿瘤活性

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Catalytic methods for the synthesis of previously unknown 2,9-disubstituted 3b R *,7a R *,10b R *,14a R *- cis -14c,14d-perhydro-2,3a,7b,9,10a,14b-hexaazadibenzotetracenes have been developed. The structures were established by 1D ( ~(1) H, ~(13) C) and 2D (COSY, HSQC, HMBC) NMR spectroscopy, MALDI TOF/TOF mass spectrometry, and X-ray diffraction analysis. Primary screening of the synthesized perhydro hexaazadibenzotetracenes for antitumor activity was carried out.

机译：用于合成的催化方法是先前未知的2,9-二取代的3b r *，7ar *，10b r *，14a r * - cis -14c，14d-perydro-2,3a，7b，9,10a，14b-六氧氮唑类异细四酸已经开发了。该结构由1D（〜（1）H，〜（13）c）和2D（Cozy，HSQC，HMBC）NMR光谱，MALDI TOF / TOF质谱法和X射线衍射分析建立。进行了抗肿瘤活性合成的Hehydro六氮杂氮烯异细四异丙苯的初次筛选。

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《RSC Advances》 |2020年第36期|共10页
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Elena B. Rakhimova; Victor Yu. Kirsanov; Elena V. Tretyakova; Leonard M. Khalilov; Askhat G. Ibragimov; Lilya U. Dzhemileva; Vladimir A. Dyakonov; Usein M. Dzhemilev;
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1. Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes [J] . Rakhimova Elena B., Kirsanov Victor Yu, Tretyakova Elena V, RSC Advances . 2020,第36期

机译：2,9-二取代的perydro 2,3a，7b，9,9,10a，14b-六氮氮向导异细胞的合成，结构和抗肿瘤活性
2. First Synthesis of 2,9-Disubstituted cis-2,3a,7b,9,10a,14b-Hexaazaperhydrodibenzotetracenes [J] . Elena B. Rakhimova, Victor Yu. Kirsanov, Ekaterina S. Mescheryakova, Synlett . 2018,第14期

机译：第一次合成2,9-二取代的顺式-2,3a，7b，9,10a，14b-六己唑氢二苯并丙烯
3. Antitumor agents 286. Design, synthesis, and structure-activity relationships of 3'R,4'R -disubstituted-2',2'-dimethyldihydropyrano[2,3- f ]chromone (DSP) analogues as potent chemosensitizers to overcome multidrug resistance [J] . Zhou T., Shi Q., Bastow K.F., Journal of Medicinal Chemistry . 2010,第24期

机译：抗肿瘤剂286。3'R，4'R-二取代-2'，2'-二甲基二氢吡喃并[2,3-f]色酮（DSP）类似物作为有效的化学增敏剂，克服了多药耐药性，其设计，合成和构效关系
4. Synthesis and Antitumor Activity of Novel 4, 5-Disubstituted Triazole Derivatives [C] . W. Y. YUAN, Y. N. WEN, N. N. Liu, International Conference on Industrial Technology and Management Science . 2015

机译：新型4,5二取代三唑衍生物的合成与抗肿瘤活性
5. Part I. Synthesis of cytochrome P450-CAM substrate analogues towards developing cytochrome P450-CAM as an enzyme-based model system for mechanistic studies of important types of P450 reactions. Part II. Diels-Alder approach towards the synthesis of 2,3-disubstituted anthracene derivatives for luminescence spectroscopy characterization: Synthesis towards fluorescent sensors. [D] . Kemnitzer, William Edward. 1998

机译：第一部分。合成细胞色素P450-CAM底物类似物，以开发细胞色素P450-CAM作为一种基于酶的模型系统，用于重要类型P450反应的机理研究。第二部分Diels-Alder合成2,3-二取代蒽衍生物以进行发光光谱表征的方法：合成荧光传感器。
6. Antitumor Agents 286. Design Synthesis and Structure-Activity Relationships of 3′R4′R-Disubstituted-2′2′-dimethyldihydropyrano23-fchromone (DSP) Analogs as Potent Chemosensitizers to Overcome Multidrug Resistance [O] . Ting Zhou, Qian Shi, Kenneth F. Bastow, -1

机译：抗肿瘤剂的3R 286的设计合成和结构 - 活性关系4R二取代的22- dimethyldihydropyrano 23-F色酮（Dsp）类似物为有效的化学敏化剂克服多药耐药
7. Antitumor Agents 286. Design, Synthesis, and Structure−Activity Relationships of 3′R,4′R-Disubstituted-2′,2′-dimethyldihydropyrano2,3-fchromone (DSP) Analogues as Potent Chemosensitizers to Overcome Multidrug Resistance [O] . Ting Zhou, Qian Shi, Kenneth F. Bastow, 2010

机译：抗肿瘤剂286. 3'R，4'R-Disubstited-2'，2'-dimethyldihydropyrano 2,3-F铬酮（DSP）类似物的设计，合成和结构 - 活性关系作为有效的化学化剂以克服多药抗性

Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes

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